ArticleBioMed research international2015
Monitoring the modifications of the vitreous humor metabolite profile after death: an animal model.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- PMI estimation through metabolomics and potassium analysis on animal vitreous humour.International journal of legal medicine · 2023Article
- The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study.Diagnostics (Basel, Switzerland) · 2022Article
- Post mortem computed tomography meets radiomics: a case series on fractal analysis of post mortem changes in the brain.International journal of legal medicine · 2022Article
- A preliminary study on early postmortem submersion interval (PMSI) estimation and cause-of-death discrimination based on nontargeted metabolomics and machine learning algorithms.International journal of legal medicine · 2022Article
- The Vital Role of Thanatochemistry in the Postmortem Diagnostic of Diabetic Ketoacidosis-Case Report.Diagnostics (Basel, Switzerland) · 2021Article
- Comparative use of aqueous humourInternational journal of legal medicine · 2021Article
- Postmortem Ocular Findings in the Optical Coherence Tomography Era: A Proof of Concept Study Based on Six Forensic Cases.Diagnostics (Basel, Switzerland) · 2021Article
- Forensic NMR metabolomics: one more arrow in the quiver.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- An evaluation of the objectivity and reproducibility of shear wave elastography in estimating the post-mortem interval: a tissue biomechanical perspective.International journal of legal medicine · 2020Article
- Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Optical coherence tomography in forensic sciences: a review of the literature.Forensic science, medicine, and pathology · 2019Review
- AMetabolomics : Official journal of the Metabolomic Society · 2019Article
- Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.Forensic toxicology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite profile) representative of the VH status at different times. Spectral data were analyzed by Principal Component Analysis (PCA) and by Orthogonal Projection to Latent Structures (OPLS) regression technique. PCA and OPLS suggested that different spectral regions were involved in time-related changes. The major time-related compositional changes, here detected, were the increase of lactate, hypoxanthine, alanine, total glutathione, choline/phosphocholine, creatine, and myo-inositol and the decrease of glucose and 3-hydroxybutyrate. We attempted a speculative interpretation of the biological mechanisms underlying these changes. These results show that multivariate statistical approach, based on (1)H NMR metabolite profiling, is a powerful tool for detecting ongoing differences in VH composition and may be applied to investigate several physiological and pathological conditions.
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