ArticleFrontiers in genetics2015
Global DNA cytosine methylation as an evolving trait: phylogenetic signal and correlated evolution with genome size in angiosperms.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 115 citations in OpenAlex.
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- DNA Methylation Dynamics in Response to Drought Stress in Crops.Plants (Basel, Switzerland) · 2024Review
- Resolving tumor evolution: a phylogenetic approach.Journal of the National Cancer Center · 2024Review
- Evolutionary insights into 3D genome organization and epigenetic landscape ofLife science alliance · 2024Article
- Sugar Concentration, Nitrogen Availability, and Phylogenetic Factors Determine the Ability of Acinetobacter spp. and Rosenbergiella spp. to Grow in Floral Nectar.Microbial ecology · 2023Article
- Genomic and epigenomic variation in Psidium species and their outcome under the yield and composition of essential oils.Scientific reports · 2023Article
- Herbivory induced methylation changes in the Lombardy poplar: A comparison of results obtained by epiGBS and WGBS.PloS one · 2023Article
- Epitype-inducing temperatures drive DNA methylation changes during somatic embryogenesis in the long-lived gymnosperm Norway spruce.Frontiers in plant science · 2023Article
- Integrated analysis of DNA methylation, transcriptome, and global metabolites in interspecific heteroticiScience · 2022Article
- Genetic and environmental drivers of large-scale epigenetic variation in Thlaspi arvense.PLoS genetics · 2022Article
- Plant DNA Methylation: An Epigenetic Mark in Development, Environmental Interactions, and Evolution.International journal of molecular sciences · 2022Review
- Are chromosome number and genome size associated with habit and environmental niche variables? Insights from the Neotropical orchids.Annals of botany · 2022Article
- Genome Assembly and Analysis of the Flavonoid and Phenylpropanoid Biosynthetic Pathways in Fingerroot Ginger (International journal of molecular sciences · 2022Article
- Adaptive Potential of Epigenetic Switching During Adaptation to Fluctuating Environments.Genome biology and evolution · 2022Article
- Epigenetics of wheat-rust interaction: an update.Planta · 2022Review
- Transition from Seeds to Seedlings: Hormonal and Epigenetic Aspects.Plants (Basel, Switzerland) · 2021Review
- CHH Methylation Islands: A Nonconserved Feature of Grass Genomes That Is Positively Associated with Transposable Elements but Negatively Associated with Gene-Body Methylation.Genome biology and evolution · 2021Article
- Atypical DNA methylation, sRNA-size distribution, and female gametogenesis in Utricularia gibba.Scientific reports · 2021Article
- Multi-omics analyses on Kandelia obovata reveal its response to transplanting and genetic differentiation among populations.BMC plant biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered gene expression, but little is known on interspecific variation in global cytosine methylation in plants. In this paper, we compare global cytosine methylation estimates obtained by HPLC and use a phylogenetically-informed analytical approach to test for significance of evolutionary signatures of this trait across 54 angiosperm species in 25 families. We evaluate whether interspecific variation in global cytosine methylation is statistically related to phylogenetic distance and also whether it is evolutionarily correlated with genome size (C-value). Global cytosine methylation varied widely between species, ranging between 5.3% (Arabidopsis) and 39.2% (Narcissus). Differences between species were related to their evolutionary trajectories, as denoted by the strong phylogenetic signal underlying interspecific variation. Global cytosine methylation and genome size were evolutionarily correlated, as revealed by the significant relationship between the corresponding phylogenetically independent contrasts. On average, a ten-fold increase in genome size entailed an increase of about 10% in global cytosine methylation. Results show that global cytosine methylation is an evolving trait in angiosperms whose evolutionary trajectory is significantly linked to changes in genome size, and suggest that the evolutionary implications of epigenetic mechanisms are likely to vary between plant lineages.
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