ArticleFrontiers in cellular neuroscience2015
Super-resolution microscopy of the synaptic active zone.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Visualizing Presynaptic Active Zones and Synaptic Vesicles.Frontiers in synaptic neuroscience · 2022Article
- The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication.Membranes · 2021Review
- Sperm Differentiation: The Role of Trafficking of Proteins.International journal of molecular sciences · 2020Review
- Super-resolution microscopy for analyzing neuromuscular junctions and synapses.Neuroscience letters · 2020Review
- Quantifying Protein Copy Number in Super Resolution Using an Imaging-Invariant Calibration.Biophysical journal · 2019Article
- Endogenous Tagging Reveals Differential Regulation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A method for estimating relative changes in the synaptic density in Drosophila central nervous system.BMC neuroscience · 2018Article
- Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons.Acta neuropathologica communications · 2018Article
- Coupling the Structural and Functional Assembly of Synaptic Release Sites.Frontiers in neuroanatomy · 2018Review
- Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.Current opinion in neurobiology · 2017Review
- A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones.Scientific reports · 2017Article
- Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.Scientific reports · 2016Article
- Synaptic Vesicle Proteins and Active Zone Plasticity.Frontiers in synaptic neuroscience · 2016Article
- Super Resolution Imaging of Genetically Labeled Synapses in Drosophila Brain Tissue.Frontiers in cellular neuroscience · 2016Article
- The Molecular Architecture of Cell Adhesion: Dynamic Remodeling Revealed by Videonanoscopy.Frontiers in cell and developmental biology · 2016Review
- Presynaptic active zones in invertebrates and vertebrates.EMBO reports · 2015Review
- Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation.Frontiers in cellular neuroscience · 2015Article
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3 authors.
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Abstract
Brain function relies on accurate information transfer at chemical synapses. At the presynaptic active zone (AZ) a variety of specialized proteins are assembled to complex architectures, which set the basis for speed, precision and plasticity of synaptic transmission. Calcium channels are pivotal for the initiation of excitation-secretion coupling and, correspondingly, capture a central position at the AZ. Combining quantitative functional studies with modeling approaches has provided predictions of channel properties, numbers and even positions on the nanometer scale. However, elucidating the nanoscopic organization of the surrounding protein network requires direct ultrastructural access. Without this information, knowledge of molecular synaptic structure-function relationships remains incomplete. Recently, super-resolution microscopy (SRM) techniques have begun to enter the neurosciences. These approaches combine high spatial resolution with the molecular specificity of fluorescence microscopy. Here, we discuss how SRM can be used to obtain information on the organization of AZ proteins.
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