Evidence map›Paper›PMID 25688177›Full record

Trial reportMediators of inflammation2015

Supplementation with red palm oil increases β-carotene and vitamin A blood levels in patients with cystic fibrosis.

Olaf Sommerburg, Silke De Spirt, Annett Mattern, Cornelia Joachim, Claus-Dieter Langhans, Kalanithi Nesaretnam, Werner Siems, Wilhelm Stahl, Marcus A Mall

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 15 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Olaf SommerburgDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany ; Translational Lung Research Centre Heidelberg (TLRC), Member of the German Centre for Lung Research (DZL), Im Neuenheimer Feld 350, 69120 Heidelberg, Germany.
Silke De SpirtInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Dusseldorf, 40001 Dusseldorf, Germany.
Annett MatternDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Cornelia JoachimDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Claus-Dieter LanghansDivision of Metabolic Diseases and Newborn Screening Centre, Department of Paediatrics I, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Kalanithi NesaretnamProduct Development and Advisory Services, Malaysian Palm Oil Board (MPOB), 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia.
Werner SiemsResearch Institute of Physiotherapy and Gerontology, KortexMed Institute of Medical Education, Hindenburgring 12a, 38667 Bad Harzburg, Germany.
Wilhelm StahlInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Dusseldorf, 40001 Dusseldorf, Germany.
Marcus A MallDivision of Pediatric Pulmonology & Allergy and Cystic Fibrosis Centre, Department of Pediatrics III, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany ; Translational Lung Research Centre Heidelberg (TLRC), Member of the German Centre for Lung Research (DZL), Im Neuenheimer Feld 350, 69120 Heidelberg, Germany ; Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany.
Heidelberg University · DEHeinrich Heine University Düsseldorf · DEGerman Center for Lung Research · DEMalaysian Palm Oil Board · MYUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with cystic fibrosis (CF) show decreased plasma concentrations of antioxidants due to malabsorption of lipid soluble vitamins and consumption by chronic pulmonary inflammation. β-Carotene is a major source of retinol and therefore is of particular significance in CF. The aim of this study was to investigate the effect of daily intake of red palm oil (RPO) containing high amounts of β-carotene on the antioxidant levels in CF patients. Sixteen subjects were recruited and instructed to enrich their food with 2 to 3 tablespoons of RPO (~1.5 mg of β-carotene) daily over 8 weeks. Carotenoids, retinol, and α-tocopherol were measured in plasma at baseline and after intervention. In addition β-carotene, lycopene, α-tocopherol, and vitamin C were measured in buccal mucosa cells (BMC) to determine the influence of RPO on antioxidant tissue levels. Eleven subjects completed the study properly. Plasma β-carotene, retinol, and α-carotene of these patients increased, but plasma concentrations of other carotenoids and α-tocopherol as well as concentrations of β-carotene, lycopene, α-tocopherol, and vitamin C in BMC remained unchanged. Since RPO on a daily basis did not show negative side effects the data suggest that RPO may be used to elevate plasma β-carotene in CF.

Indexed as

AdolescentAdultbeta CaroteneCarotenoidsChildCystic FibrosisDietary SupplementsFemaleHumansLycopeneMalePalm OilPlant OilsVitamin AYoung Adultbeta CaroteneCarotenoidsLycopenePalm OilPlant OilsVitamin A

Identifiers

PMID25688177
PMCPMC4321850
OpenAlexW2045066955

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.