ArticleGenome biology and evolution2015
Molecular evolution of cytochrome bd oxidases across proteobacterial genomes.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- A cytochromeApplied and environmental microbiology · 2025Article
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- The radical impact of oxygen on prokaryotic evolution-enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third.FEBS letters · 2024Article
- Response ofInternational journal of molecular sciences · 2022Article
- Mechanistic and structural diversity between cytochromeProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genomic evolution of the class Acidithiobacillia: deep-branching Proteobacteria living in extreme acidic conditions.The ISME journal · 2021Article
- Bacterial Oxidases of the CytochromeAntioxidants & redox signaling · 2021Review
- Cardiolipin enhances the enzymatic activity of cytochrome bd and cytochrome boScientific reports · 2021Article
- Oxygen Reductases in Alphaproteobacterial Genomes: Physiological Evolution From Low to High Oxygen Environments.Frontiers in microbiology · 2019Article
- Microbes vs. chemistry in the origin of the anaerobic gut lumen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor.Frontiers in microbiology · 2018Article
- The CytochromeFrontiers in microbiology · 2018Article
- The functional microbiome of arthropods.PloS one · 2017Article
- Alpha proteobacterial ancestry of the [Fe-Fe]-hydrogenases in anaerobic eukaryotes.Biology direct · 2016Article
- Late Mitochondrial Acquisition, Really?Genome biology and evolution · 2016Article
- The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth.Scientific reports · 2016Article
- Genome Analysis of Structure-Function Relationships in Respiratory Complex I, an Ancient Bioenergetic Enzyme.Genome biology and evolution · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work is aimed to resolve the complex molecular evolution of cytochrome bd ubiquinol oxidase, a nearly ubiquitous bacterial enzyme that is involved in redox balance and bioenergetics. Previous studies have created an unclear picture of bd oxidases phylogenesis without considering the existence of diverse types of bd oxidases. Integrated approaches of genomic and protein analysis focused on proteobacteria have generated a molecular classification of diverse types of bd oxidases, which produces a new scenario for interpreting their evolution. A duplication of the original gene cluster of bd oxidase might have occurred in the ancestors of extant α-proteobacteria of the Rhodospirillales order, such as Acidocella, from which the bd-I type of the oxidase might have diffused to other proteobacterial lineages. In contrast, the Cyanide-Insensitive Oxidase type may have differentiated into recognizable subtypes after another gene cluster duplication. These subtypes are widespread in the genomes of α-, β-, and γ-proteobacteria, with occasional instances of lateral gene transfer. In resolving the evolutionary pattern of proteobacterial bd oxidases, this work sheds new light on the basal taxa of α-proteobacteria from which the γ-proteobacterial lineage probably emerged.
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