ReviewNature reviews. Clinical oncology2015
Can oncology recapitulate paleontology? Lessons from species extinctions.
Review in Nature reviews. Clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network.Heliyon · 2024Article
- Treatment of evolving cancers will require dynamic decision support.Annals of oncology : official journal of the European Society for Medical Oncology · 2023Review
- Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal "unity of ecology and evolution" pathological ecosystem.Theranostics · 2023Review
- The future of evolutionary medicine: sparking innovation in biomedicine and public health.Frontiers in science · 2023Article
- Pancreatic cancer pathology viewed in the light of evolution.Cancer metastasis reviews · 2021Review
- Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy.NPJ breast cancer · 2021Review
- Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer.International journal of molecular sciences · 2020Article
- Integrating evolutionary dynamics into cancer therapy.Nature reviews. Clinical oncology · 2020Review
- Characterizing the ecological and evolutionary dynamics of cancer.Nature genetics · 2020Review
- Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.Nature genetics · 2020Article
- Eradicating Metastatic Cancer and the Eco-Evolutionary Dynamics of Anthropocene Extinctions.Cancer research · 2020Article
- Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics.International journal of molecular sciences · 2019Review
- First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction.Cancer research · 2019Article
- Tumor evolution: Linear, branching, neutral or punctuated?Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Spatial Heterogeneity in the Tumor Microenvironment.Cold Spring Harbor perspectives in medicine · 2016Review
- When (distant) relatives stay too long: implications for cancer medicine.Genome biology · 2016Article
- Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors.Journal of Cancer · 2016Review
- Genome management and mismanagement--cell-level opportunities and challenges of whole-genome duplication.Genes & development · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Although we can treat cancers with cytotoxic chemotherapies, target them with molecules that inhibit oncogenic drivers, and induce substantial cell death with radiation, local and metastatic tumours recur, resulting in extensive morbidity and mortality. Indeed, driving a tumour to extinction is difficult. Geographically dispersed species of organisms are perhaps equally resistant to extinction, but >99.9% of species that have ever existed on this planet have become extinct. By contrast, we are nowhere near that level of success in cancer therapy. The phenomena are broadly analogous--in both cases, a genetically diverse population mutates and evolves through natural selection. The goal of cancer therapy is to cause cancer cell population extinction, or at least to limit any further increase in population size, to prevent the tumour burden from overwhelming the patient. However, despite available treatments, complete responses are rare, and partial responses are limited in duration. Many patients eventually relapse with tumours that evolve from cells that survive therapy. Similarly, species are remarkably resilient to environmental change. Paleontology can show us the conditions that lead to extinction and the characteristics of species that make them resistant to extinction. These lessons could be translated to improve cancer therapy and prognosis.
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Registered trials
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