Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. DNA polymerase theta (Polθ): a novel candidate for targeted cancer therapy.Cancer biology & therapy · 2026
   Review
2. Natural products targeting cancer cell dependency.The Journal of antibiotics · 2021
   Review
3. Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy.Cancer drug resistance (Alhambra, Calif.) · 2021
   Article
4. Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.BMC medical genetics · 2020
   Article
5. Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses.NAR cancer · 2020
   Article
6. Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations.Cancers · 2020
   Review
7. Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.The EMBO journal · 2017
   Article
8. Paths from DNA damage and signaling to genome rearrangements via homologous recombination.Mutation research · 2017
   Review
9. Drugging the Cancers Addicted to DNA Repair.Journal of the National Cancer Institute · 2017
   Review
10. Dual loss of human POLQ and LIG4 abolishes random integration.Nature communications · 2017
    Article
11. Translational research in radiation-induced DNA damage signaling and repair.Translational cancer research · 2017
    Article

Corrections and comments

• Comment on
  Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.2015
• Comment on
  Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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