ArticleCancer research and treatment2015
Long-Term Outcome of Definitive Radiotherapy for Early Glottic Cancer: Prognostic Factors and Patterns of Local Failure.
Article in Cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Stereotactic body radiotherapy for early glottic cancers: Is this "The Way"?Clinical and translational radiation oncology · 2025Review
- Impact of anterior commissure invasion on the oncological efficacy of transoral laser microsurgery for T1 glottic cancer.Frontiers in oncology · 2025Article
- Assessment and validation of glottic motion using cone-beam CT and real-time cine MRI.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Oncological and Functional Outcomes for Horizontal Glottectomy: A Systematic Review.Journal of clinical medicine · 2023Review
- Long-term impact of smoking cessation on new glottic cancer events in patients with early glottic cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Prospective Observational Comparative Study of Response and Toxicities in Early Glottic Cancer Using Telecobalt Versus 3D-CRT.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Hypofractionated radiotherapy for early stage glottic cancer: efficacy of 3.5 Gy per fraction.Radiation oncology journal · 2022Article
- Prognostic value of the maximum standardized uptake value for the locoregional control in early glottic cancer.Radiation oncology journal · 2021Article
- Individualized quality of life benefit and cost-effectiveness estimates of proton therapy for patients with oropharyngeal cancer.Radiation oncology (London, England) · 2021Article
- Chemoradiotherapy for high-risk stage II laryngeal cancer.International journal of clinical oncology · 2020Article
- Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.The Laryngoscope · 2020Article
- Prognostic factors in patients with T1 glottic cancer treated with radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- Involvement of the Anterior Commissure in Early Glottic Cancer (Tis-T2): A Review of the Literature.Cancers · 2019Review
- Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution.Radiation oncology journal · 2019Article
- Outcome of Early-Stage Glottic Laryngeal Carcinoma Patients Treated with Radical Radiotherapy Using Different Techniques.Journal of oncology · 2019Article
- Endoscopic-assisted selective neck dissection via small lateral neck incision for early-stage (T1-2N0M0) head and neck squamous cell carcinoma: 3-year follow-up results.Surgical endoscopy · 2017Article
- Impact of Close and Positive Margins in Transoral Laser Microsurgery for Tis-T2 Glottic Cancer.Frontiers in oncology · 2017Article
- Volumetric modulated arc radiotherapy of the whole larynx, followed by a single affected vocal cord, for T1a glottic cancer: Dosimetric analysis of a case.Molecular and clinical oncology · 2016Article
- Clinical Outcomes of Radiotherapy for Stage 1 Glottic Carcinoma: Comparing Accelerated Hyperfractionation and Once-daily Fractionation.In vivo (Athens, Greece)Article
- Clinical Application Study of Semi-cylindrical Beam Spoiler for Radiation Treatment of Early-stage Glottic Cancer Patients.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study evaluates the long-term results of definitive radiotherapy (RT) for early glottic cancer. Clinical and treatment factors related to local control and patterns of failure are analyzed. MATERIALS AND
methodsWe retrospectively reviewed 222 patients with T1-2N0 squamous cell carcinoma of the glottic larynx treated with definitive RT from 1981 to 2010. None of the patients received elective nodal RT or combined chemotherapy. The median total RT dose was 66 Gy. The daily fraction size was < 2.5 Gy in 69% and 2.5 Gy in 31% of patients. The RT field extended from the hyoid bone to the cricoid cartilage.
resultsThe median age was 60 years, and 155 patients (70%) had T1 disease. The 5-year rates of local recurrence-free survival (LRFS) and ultimate LRFS with voice preservation were 87.8% and 90.3%, respectively. T2 (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.08 to 4.94) and anterior commissural involvement (HR, 3.37; 95% CI, 1.62 to 7.02) were significant prognostic factors for LRFS. In 34 patients with local recurrence, tumors recurred in the ipsilateral vocal cord in 28 patients. There were no contralateral vocal cord recurrences. Most acute complications included grade 1-2 dysphagia and/or hoarseness. There was no grade 3 or greater chronic toxicity.
conclusionDefinitive RT achieved a high cure rate, voice preservation, and tolerable toxicity in early glottic cancer. T2 stage and anterior commissural involvement were prognostic factors for local control. Further optimization of the RT method is needed to reduce the risk of ipsilateral tumor recurrence.
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