Evidence map›Paper›PMID 25687828›Full record

ArticleJournal of the American Chemical Society2015

Reversible energy-transfer switching on a DNA scaffold.

Magnus Bälter, Martin Hammarson, Patricia Remón, Shiming Li, Nittaya Gale, Tom Brown, Joakim Andréasson

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magnus BälterDepartment of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology , 412 96 Göteborg, Sweden.
Martin Hammarson
Patricia Remón
Shiming Li
Nittaya Gale
Tom Brown
Joakim Andréasson

Funding

Biotechnology and Biological Sciences Research Council BB/J001694/1
6 · The paper itself

Abstract

We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.

Indexed as

Fluorescence Resonance Energy TransferBase SequenceDNAFluorescent DyesModels, MolecularNucleic Acid ConformationDNAFluorescent Dyes

Identifiers

PMID25687828
PMCPMC4353014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.