ReviewNature reviews. Cardiology2015
Prehypertension--prevalence, health risks, and management strategies.
Review in Nature reviews. Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 5 syntheses or guidelines pooled it, 238 citations in OpenAlex.
- Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis.Current hypertension reviews · 2024Pooled it
- Short-term efficacy of non-pharmacological interventions for global population with elevated blood pressure: A network meta-analysis.Frontiers in public health · 2022Pooled it
- Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health.European journal of nutrition · 2021Pooled it
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 1 - Concept, Epidemiology and Primary PreventionArquivos brasileiros de cardiologia · 2016Guideline
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 5 - Therapeutic Decision and TargetsArquivos brasileiros de cardiologia · 2016Guideline
- Efficacy of mental and physical training on blood pressure and resting heart rate among physically inactive young adults with elevated blood pressure: a randomized controlled trial.Scientific reports · 2026Trial
- Dietary management and aerobic exercise counselling on blood pressure control in subjects with prehypertension and drug-naïve stage 1 hypertension: a randomized clinical trial.Scientific reports · 2025Trial
- Effect of Tai Chi vs Aerobic Exercise on Blood Pressure in Patients With Prehypertension: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Home-based transcutaneous electrical acupoint stimulation for high-normal blood pressure: A randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2022Trial
- Stage I hypertension is associated with impaired systolic function by strain imaging compared with prehypertension: A report from the prever study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- Randomised, double-blind, placebo-controlled, assessment of the efficacy and safety of dietary supplements in prehypertension.Journal of human hypertension · 2017Trial
- Cardiovascular Diseases and All-Cause Mortality Risk in Patients With Prehypertension and Noncommunicable Diseases: Results From the Kailuan Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Prehypertension in young physically active adults: early vascular alterations and implications for exercise-intensity prescription.Frontiers in cardiovascular medicine · 2026Article
- Intensive blood pressure control to prevent major cardiovascular events in individuals with high-normal blood pressure (prehypertension): PRINT-TAHA9 randomized clinical trial.Clinical hypertension · 2026Article
- Prevalence of Prehypertension Among Adults in Baghdad/Iraq.International journal of hypertension · 2026Article
- Pre-hypertension in Bangladesh: evidence from BDHS 2022.Frontiers in public health · 2026Article
- Six Weeks of Boxing Training Lowers Blood Pressure and Improves Vascular Function in Young Men and Women with Elevated Blood Pressure or Stage 1 Hypertension.Sports (Basel, Switzerland) · 2026Article
- Surgery and Acute Stress Decrease NRF2 mRNA Expression and Promote Iron Metabolism Alteration, Oxidative Stress, and Inflammatory Gene Expression in the Liver of Prehypertensive Rats.Physiological research · 2025Article
- Article
- Development of a nomogram prediction model for thrombolytic outcomes in acute ischemic stroke.BMC neurology · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prehypertension (blood pressure 120-139/80-89 mmHg) affects ~25-50% of adults worldwide, and increases the risk of incident hypertension. The relative risk of incident hypertension declines by ~20% with intensive lifestyle intervention, and by 34-66% with single antihypertensive medications. To prevent one case of incident hypertension in adults with prehypertension and a 50% 5-year risk of hypertension, 10 individuals would need to receive intensive lifestyle intervention, and four to six patients would need to be treated with antihypertensive medication. The relative risk of incident cardiovascular disease (CVD) is greater with 'stage 2' (130-139/85-89 mmHg) than 'stage 1' (120-129/80-84 mmHg) prehypertension; only stage 2 prehypertension increases cardiovascular mortality. Among individuals with prehypertension, the 10-year absolute CVD risk for middle-aged adults without diabetes mellitus or CVD is ~10%, and ~40% for middle-aged and older individuals with either or both comorbidities. Antihypertensive medications reduce the relative risk of CVD and death by ~15% in secondary-prevention studies of prehypertension. Data on primary prevention of CVD with pharmacotherapy in prehypertension are lacking. Risk-stratified, patient-centred, comparative-effectiveness research is needed in prehypertension to inform an acceptable, safe, and effective balance of lifestyle and medication interventions to prevent incident hypertension and CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.