ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2015
High-resolution crystal structure of Z-DNA in complex with Cr(3+) cations.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Reassessing the Significance of Chromium-DNA Adducts in Chromate Carcinogenicity.Biological trace element research · 2026Review
- Do Ternary DNA-Cr(III)-Small Molecule Adducts Form?Biological trace element research · 2025Review
- Right-handed Z-DNA at ultrahigh resolution: a tale of two hands and the power of the crystallographic method.Acta crystallographica. Section D, Structural biology · 2023Article
- Crystallization of Z-DNA in Complex with Chemical and Z-DNA Binding Z-Alpha Protein.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Nonalternating purine pyrimidine sequences can form stable left-handed DNA duplex by strong topological constraint.Nucleic acids research · 2022Article
- Crystal structure of Z-DNA in complex with the polyamine putrescine and potassium cations at ultra-high resolution.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2021Article
- Conformation-dependent restraints for polynucleotides: the sugar moiety.Nucleic acids research · 2020Article
- Polarizable Force Field for DNA Based on the Classical Drude Oscillator: II. Microsecond Molecular Dynamics Simulations of Duplex DNA.Journal of chemical theory and computation · 2017Article
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5 authors.
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Abstract
This work is part of our project aimed at characterizing metal-binding properties of left-handed Z-DNA helices. The three Cr(3+) cations found in the asymmetric unit of the d(CGCGCG)2-Cr(3+) crystal structure do not form direct coordination bonds with atoms of the Z-DNA molecule. Instead, the hydrated Cr(3+) ions are engaged in outer-sphere interactions with phosphate groups and O6 and N7 guanine atoms of the DNA. The Cr(3+)(1) and Cr(3+)(2) ions have disordered coordination spheres occupied by six water molecules each. These partial-occupancy chromium cations are 2.354(15) Å apart and are bridged by three water molecules from their hydration spheres. The Cr(3+)(3) cation has distorted square pyramidal geometry. In addition to the high degree of disorder of the DNA backbone, alternate conformations are also observed for the deoxyribose and base moieties of the G2 nucleotide. Our work illuminates the question of conformational flexibility of Z-DNA and its interaction mode with transition-metal cations.
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