Evidence map›Paper›PMID 25687449›Full record

ArticleNuclear medicine and biology2015

[(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

Yongjun Gao, Ronnie C Mease, Thao T Olson, Kenneth J Kellar, Robert F Dannals, Martin G Pomper, Andrew G Horti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongjun GaoRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
Ronnie C MeaseRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
Thao T OlsonDepartment of Pharmacology & Physiology, Georgetown University School of Medicine, Washington, DC.
Kenneth J KellarDepartment of Pharmacology & Physiology, Georgetown University School of Medicine, Washington, DC.
Robert F DannalsRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
Andrew G HortiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: ahorti1@jhmi.edu.

Funding

Extrathalamic nAChR-PET for Imaging NeurodegenerationR33AG037298 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2012 to 2014
$1.2M
Extrathalamic nAChR-PET for Imaging NeurodegenerationR21AG037298 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2011 to 2011
$235k
NIA NIH HHS AG037298NIA NIH HHS R21 AG037298NIA NIH HHS R33 AG037298
6 · The paper itself

Abstract

[(125)I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (K(i) = 0.5 nM; α7/α4β2 = 3414), has been synthesized in radiochemical yield of 33 ± 6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1600Ci/mmol; 59.2 MBq/μmol). [(125)I]Iodo-ASEM readily entered the brains of normal CD-1 mice and specifically and selectively labeled cerebral α7-nAChRs. [(125)I]iodo-ASEM is a new useful tool for studying α7-nAChR.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsAzabicyclo CompoundsBrainCyclic S-OxidesHEK293 CellsHumansIodine RadioisotopesLigandsMaleMiceRadiochemistryReceptors, NicotinicReceptors, Serotonin, 5-HT3Substrate Specificity3-(1,4-diazabicyclo(3.2.2)nonan-4-yl)-6-fluorodibenzo(b,d)thiophene 5,5-dioxidealpha7 Nicotinic Acetylcholine ReceptorAzabicyclo CompoundsCyclic S-OxidesIodine RadioisotopesLigandsnicotinic receptor alpha4beta2Receptors, NicotinicReceptors, Serotonin, 5-HT3iodo-ASEMNicotinic acetylcholine receptorSPECTα7-nAChR

Identifiers

PMID25687449
PMCPMC4387010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.