Observational studyClinical research in cardiology : official journal of the German Cardiac Society2015
Acute coronary syndrome in young women under 55 years of age: clinical characteristics, treatment, and outcomes.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The Risk Factors of Acute Coronary Syndrome in Young Women: A Systematic Review and Meta-Analysis.Current cardiology reviews · 2023Pooled it
- Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review.BMJ (Clinical research ed.) · 2020Pooled it
- Prevalence of physical activity and its association with atherosclerotic cardiovascular risk factors in young women in the middle east: a sub-analysis of the ANCHORS study.BMC public health · 2025Observational
- Gender inequalities in secondary prevention of cardiovascular disease: a scoping review.International journal for equity in health · 2024Article
- Gender-Related Factors Associated With Outcomes of Acute Coronary Syndrome in Young Female Patients.CJC open · 2024Review
- Sex-Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study.Journal of the American Heart Association · 2023Article
- Characteristics and treatment analysis of young acute coronary syndrome patients in a tertiary care hospital: A cross-sectional retrospective study.Health science reports · 2023Article
- Clinical characteristics and cardiovascular outcomes among young patients with acute myocardial infarction in Kerala, India: A secondary analysis of ACS QUIK trial.Atherosclerosis plus · 2022Article
- Risk of Ischemic Heart Disease Associated with Primary Dysmenorrhea: A Population-Based Retrospective Cohort Study.Journal of personalized medicine · 2022Article
- Impact of risk factors related to metabolic syndrome on acute myocardial infarction in younger patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study.Journal of the American Heart Association · 2022Article
- Sex-Related Differences in Long-Term Outcomes After Early-Onset Myocardial Infarction.Frontiers in cardiovascular medicine · 2022Article
- The Most Relevant Factors Affecting the Perioperative Death Rate in Patients with Acute Coronary Syndrome and COVID-19, Based on Annual Follow-Up in the ORPKI Registry.Biomedicines · 2021Article
- Sex-Specific Plaque Signature: Uniqueness of Atherosclerosis in Women.Current cardiology reports · 2021Review
- Sex Differences on Clinical Characteristics, Severity, and Mortality in Adult Patients With COVID-19: A Multicentre Retrospective Study.Frontiers in medicine · 2021Article
- Women who experience a myocardial infarction at a young age have worse outcomes compared with men: the Mass General Brigham YOUNG-MI registry.European heart journal · 2020Article
- Gender Differences in Residual Risk Factors for Major Adverse Cardiovascular Events Following ACS and How to Bridge the Gap.Current atherosclerosis reports · 2020Review
- Sex-Specific Outcomes in Patients with Acute Coronary Syndrome.Journal of clinical medicine · 2020Article
- Sex-related differences in the association between plasma fibrinogen and non-calcified or mixed coronary atherosclerotic plaques.Biology of sex differences · 2018Article
- Warning Against Low-Density Lipoprotein Oxidation in Users of Oral Combined Contraceptives.Arquivos brasileiros de cardiologia · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYoung women with acute coronary syndrome (ACS) may represent a high risk group, but little is known about specific age and sex differences in clinical characteristics, treatment, outcomes, and trends over time.
methodsData from 3237 men and women admitted with an ACS event from 1999 to 2006 were analyzed. Patients were grouped by sex and age less than 55 years. Demographics, presentation, treatment, and outcomes at 6 months were analyzed. Primary outcomes included mortality, recurrent myocardial infarction, rehospitalization, and stroke at 6 months. Secondary analyses assessed risk factors, management, and trends over time.
resultsWomen under 55 years represented 8% of the entire cohort, and 26% of patients under age 55 years. Compared to older women, young women were more likely to be smokers (51 vs. 14%, p < 0.001) and obese (44 vs. 34%, p = 0.006). Young women had more diabetes and hypertension than young men. Mortality was lowest among young women and did not change over time. Young women received less treatment with aspirin, beta blockers, lipid-lowering agents, and ACE inhibitors, and underwent less coronary angiography and stenting than young men (44 vs. 59%, p < 0.001). Rehospitalization was higher among young women than young men (37 vs. 27%, p < 0.001), with no change over time.
conclusionsModifiable risk factors such as smoking, obesity, diabetes, and hypertension should be addressed in young women. Following ACS, young women received fewer evidence-based medications, were treated less invasively, and had higher readmission rates within 6 months compared to young men.
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