ArticleScientific reports2015
Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Dual roles for influenza A protein PA-X: limiting inflammatory response and disrupting MHC I antigen presentation in human respiratory epithelium.bioRxiv : the preprint server for biology · 2026Article
- A Narrative Review on the Multifaceted Roles of Galectins in Host-Pathogen Interactions DuringInternational journal of molecular sciences · 2025Review
- Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin.Signal transduction and targeted therapy · 2025Article
- Molecular signatures of alveolar type II cell differentiation in acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- Influenza Virus Host Restriction Factors: The ISGs and Non-ISGs.Pathogens (Basel, Switzerland) · 2024Review
- Single-cell genome-wide association reveals that a nonsynonymous variant inCell genomics · 2022Article
- GeneticInternational journal of molecular sciences · 2022Article
- SPINK6 inhibits human airway serine proteases and restricts influenza virus activation.EMBO molecular medicine · 2022Article
- Galectins: An Ancient Family of Carbohydrate Binding Proteins with Modern Functions.Methods in molecular biology (Clifton, N.J.) · 2022Review
- A natural variant in ANP32B impairs influenza virus replication in human cells.The Journal of general virology · 2021Article
- The Antiviral Role of Galectins toward Influenza A Virus Infection-An Alternative Strategy for Influenza Therapy.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses.Cold Spring Harbor perspectives in medicine · 2021Review
- Pathogenetic profiling of COVID-19 and SARS-like viruses.Briefings in bioinformatics · 2021Article
- Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset.International journal of general medicine · 2021Article
- Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis.Scientific reports · 2020Article
- Utilization of Galectins by Pathogens for Infection.Frontiers in immunology · 2020Review
- Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans.Pathogens (Basel, Switzerland) · 2019Review
- Host susceptibility to severe influenza A virus infection.Critical care (London, England) · 2019Review
- IFITM3: How genetics influence influenza infection demographically.Biomedical journal · 2019Review
- Influenza virus N-linked glycosylation and innate immunity.Bioscience reports · 2019Review
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26 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The fatality of avian influenza A(H7N9) infection in humans was over 30%. To identify human genetic susceptibility to A(H7N9) infection, we performed a genome-wide association study (GWAS) involving 102 A(H7N9) patients and 106 heavily-exposed healthy poultry workers, a sample size critically restricted by the small number of human A(H7N9) cases. To tackle the stringent significance cutoff of GWAS, we utilized an artificial imputation program SnipSnip to improve the association signals. In single-SNP analysis, one of the top SNPs was rs13057866 of LGALS1. The artificial imputation (AI) identified three non-genotyped causal variants, which can be represented by three anchor/partner SNP pairs rs13057866/rs9622682 (AI P = 1.81 × 10(-7)), rs4820294/rs2899292 (2.13 × 10(-7)) and rs62236673/rs2899292 (4.25 × 10(-7)) respectively. Haplotype analysis of rs4820294 and rs2899292 could simulate the signal of a causal variant. The rs4820294/rs2899292 haplotype GG, in association with protection from A(H7N9) infection (OR = 0.26, P = 5.92 × 10(-7)) correlated to significantly higher levels of LGALS1 mRNA (P = 0.050) and protein expression (P = 0.025) in lymphoblast cell lines. Additionally, rs4820294 was mapped as an eQTL in human primary monocytes and lung tissues. In conclusion, functional variants of LGALS1 causing the expression variations are contributable to the differential susceptibility to influenza A(H7N9).
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