Evidence map›Paper›PMID 25687190›Full record

ReviewMethods (San Diego, Calif.)2015

Computational analysis of RNA structures with chemical probing data.

Ping Ge, Shaojie Zhang

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ping GeDepartment of Electrical Engineering and Computer Science, University of Central Florida, Orlando, FL 32816-2362, USA.
Shaojie ZhangDepartment of Electrical Engineering and Computer Science, University of Central Florida, Orlando, FL 32816-2362, USA. Electronic address: shzhang@eecs.ucf.edu.

Funding

RNA Structural Motif Analysis Revisited: Towards a Systematic Understanding of Noncoding RNA as Modular BiomoleculesR01GM102515 · NIGMS · UNIVERSITY OF CENTRAL FLORIDA · PI ZHANG, SHAOJIE, ZHONG, CUNCONG · 2012 to 2025
$2.3M
NIGMS NIH HHS R01 GM102515NIGMS NIH HHS R01GM102515
6 · The paper itself

Abstract

RNAs play various roles, not only as the genetic codes to synthesize proteins, but also as the direct participants of biological functions determined by their underlying high-order structures. Although many computational methods have been proposed for analyzing RNA structures, their accuracy and efficiency are limited, especially when applied to the large RNAs and the genome-wide data sets. Recently, advances in parallel sequencing and high-throughput chemical probing technologies have prompted the development of numerous new algorithms, which can incorporate the auxiliary structural information obtained from those experiments. Their potential has been revealed by the secondary structure prediction of ribosomal RNAs and the genome-wide ncRNA function annotation. In this review, the existing probing-directed computational methods for RNA secondary and tertiary structure analysis are discussed.

Indexed as

AlgorithmsComputational BiologyNucleic Acid ConformationRNASequence Analysis, RNASoftwareRNAchemical probingparallel sequencingRNA secondary structureRNA tertiary structure

Identifiers

PMID25687190
PMCPMC4437859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.