Evidence map›Paper›PMID 25686982›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2015

Development and evaluation of elastomeric hollow fiber membranes as small diameter vascular graft substitutes.

Ángel E Mercado-Pagán, Yunqing Kang, Michael W Findlay, Yunzhi Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ángel E Mercado-PagánDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Yunqing KangDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Michael W FindlayDepartment of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA, USA; University of Melbourne Department of Surgery, Royal Melbourne Hospital, Parkville, VIC, Australia.
Yunzhi YangDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA. Electronic address: ypyang@stanford.edu.
Stanford University · US

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R01AR057837NIDCR NIH HHS R01 DE021468NIDCR NIH HHS R01DE021468
6 · The paper itself

Abstract

Engineering of small diameter (<6mm) vascular grafts (SDVGs) for clinical use remains a significant challenge. Here, elastomeric polyester urethane (PEU)-based hollow fiber membranes (HFMs) are presented as an SDVG candidate to target the limitations of current technologies and improve tissue engineering designs. HFMs are fabricated by a simple phase inversion method. HFM dimensions are tailored through adjustments to fabrication parameters. The walls of HFMs are highly porous. The HFMs are very elastic, with moduli ranging from 1-4MPa, strengths from 1-5MPa, and max strains from 300-500%. Permeability of the HFMs varies from 0.5-3.5×10(-6)cm/s, while burst pressure varies from 25 to 35psi. The suture retention forces of HFMs are in the range of 0.8 to 1.2N. These properties match those of blood vessels. A slow degradation profile is observed for all HFMs, with 71 to 78% of the original mass remaining after 8weeks, providing a suitable profile for potential cellular incorporation and tissue replacement. Both human endothelial cells and human mesenchymal stem cells proliferate well in the presence of HFMs up to 7days. These results demonstrate a promising customizable PEU HFMs for small diameter vascular repair and tissue engineering applications.

Indexed as

Biocompatible MaterialsBlood Vessel ProsthesisCell ProliferationCells, CulturedElasticityElastomersEndothelial CellsHumansMembranes, ArtificialMesenchymal Stem CellsPermeabilityPolyestersPolymersPorosityTissue EngineeringTransplantsBiocompatible Materialselastomeric polymerElastomersMembranes, ArtificialPolyestersPolymersElastomersHollow fiber membranesPhase inversionPolyester urethanesSmall diameter vascular grafts

Identifiers

PMID25686982
PMCPMC4911220
OpenAlexW2019662096

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.