ArticleVeterinary research communications2015
The influence of enrofloxacin, florfenicol, ceftiofur and E. coli LPS interaction on T and B cells subset in chicks.
Article in Veterinary research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- Early post-hatching effects of antibiotics and ionophore coccidiostat supplementation on immune parameters in turkeys.Poultry science · 2025Article
- A comparative evaluation of antibiotic and synbiotic supplementation on production performance and necrotic enteritis severity in broilers during an experimental necrotic enteritis challenge.Frontiers in physiology · 2024Article
- Impact of dietary-nucleotides and Saccharomyces cerevisiae-derivatives on growth-performance, antioxidant-capacity, immune-response, small-intestine histomorphometry, caecal-International journal of veterinary science and medicine · 2024Article
- Article
- Characterizing the influence of various antimicrobials used for metaphylaxis against bovine respiratory disease on host transcriptome responses.Frontiers in veterinary science · 2023Article
- Effects of Total Flavonoids ofAntioxidants (Basel, Switzerland) · 2022Article
- The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.).Environmental science and pollution research international · 2022Article
- Immune Parameters in Chickens Treated with Antibiotics and Probiotics during Early Life.Animals : an open access journal from MDPI · 2022Article
- Comparative Study on Synergistic Toxicity of Enrofloxacin Combined with Three Antibiotics on Proliferation of THLE-2 Cell.Antibiotics (Basel, Switzerland) · 2022Article
- Changes in immune system and intestinal bacteria of cows during the transition period.Veterinary and animal science · 2021Article
- Effects of Artemisia argyi flavonoids on growth performance and immune function in broilers challenged with lipopolysaccharide.Animal bioscience · 2021Article
- Oxidative and Epigenetic Changes and Gut Permeability Response in Early-Treated Chickens with Antibiotic or Probiotic.Animals : an open access journal from MDPI · 2020Article
- A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions.Frontiers in immunology · 2020Article
- Ceftiofur hydrochloride affects the humoral and cellular immune response in pigs after vaccination against swine influenza and pseudorabies.BMC veterinary research · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the influence of enrofloxacin, florfenicol, ceftiofur and E. coli LPS interaction on T and B subsets in thymus and spleen of newly-hatched chicks. A 126, 1-day-old chicks were administered enrofloxacin, florfenicol or ceftiofur in recommended doses according to the currently treatment schedule advises. E .coli LPS was given intravenously once at the dose of 200 μg kg(-1) BW on the 2nd day of experiment (d. e.). On the 6th and the 14th d. e. thymus and spleens were subjected to flow cytometry investigation.The most significant changes were demonstrated in spleen. The antibiotics administration decreased the percentage of B and T cells subset. Moreover, this suppressive effect was enhanced by E. coli LPS administration. On the 6th d. e. the percentage of CD3(+)TCRγδ(-), CD3(+)TCRγδ(+), CD4(+)CD8(-), CD4(-)CD8(+) decreased significantly after ceftiofur and LPS treatment. A lower percentage of CD3(+)TCRγδ(-), CD4(-)CD8(+) and CD3(+)TCRγδ(+) was observed in enrofloxacine and LPS treated group. The decrease percentage of CD3(+)TCRγδ(+)cells and Bu-1(+) was found after florfenicol and LPS treatment. On the 14th d. e. a decreased percentage of CD4(+)CD8(-) and increased percentage of CD4(-)CD8(+) cells was shown in ceftiofur or enrofloxacine and LPS treated groups. In addition decreased percentage of CD3(+)TCRγδ(+) was found in all antibiotic and LPS treated groups.In this study, it was shown that enrofloxacine, florfenicol, ceftiofur treatment may change the proportions among lymphocytes subset and might have an impact on the immune response to bacterial endotoxins in chicks.
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