Evidence map›Paper›PMID 25686757›Full record

ReviewNature reviews. Neurology2015

Age-related hearing impairment-a risk factor and frailty marker for dementia and AD.

Francesco Panza, Vincenzo Solfrizzi, Giancarlo Logroscino

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04593290 (Listen Carefully), which is not on this map. Cited by 124 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04593290 nacompletednot on this mapstarted 2020, after this paper: background citation

Listen Carefully: An Exploratory Study of the Association Between Listening Effort and Cognitive Function

TypeinterventionalSponsorTechnical University of DenmarkRan2020 to 2021Enrolled24ConditionsCognitive Impairment, Mild, Hearing LossArmsOticon Opn S 1 miniRITE hearing aid
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 3 syntheses or guidelines pooled it, 246 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Hearing impairment and risk of Alzheimer's disease: a meta-analysis of prospective cohort studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Review
  11. "The sound of silence": when the brain doesn't hear.Aging clinical and experimental research · 2026
    Review
  12. Extended high-frequency audiometry in older adults: hearing thresholds.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Hearing Loss and Cognitive Function: An Analysis in Older Adults at the Beginning of the Auditory Rehabilitation Process.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  19. Article
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Francesco Panza1] Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Policlinico, Piazza Giulio Cesare, 11, Bari, Italy. [2] Department of Clinical Research in Neurology, University of Bari Aldo Moro, "Pia Fondazione Cardinale G. Panico", Via San Pio, 4, Tricase, Lecce, Italy.
Vincenzo SolfrizziGeriatric Medicine-Memory Unit and Rare Disease Centre, Interdisciplinary Medicine Department, University of Bari Aldo Moro, Policlinico, Piazza Giulio Cesare, 11, Bari, Italy.
Giancarlo Logroscino1] Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Policlinico, Piazza Giulio Cesare, 11, Bari, Italy. [2] Department of Clinical Research in Neurology, University of Bari Aldo Moro, "Pia Fondazione Cardinale G. Panico", Via San Pio, 4, Tricase, Lecce, Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related hearing impairment (ARHI, also known as presbycusis) is potentially a reversible risk factor for dementia and Alzheimer disease (AD). Social isolation, loneliness, poor verbal communication, and cognitive reserve depletion might causally link ARHI with cognitive impairment. ARHI is an important frailty marker, and several factors related to physical frailty could be associated with cognitive impairment. Such factors include inflammatory markers and vascular factors, which might also directly contribute to ARHI. Randomized controlled trials of potential interventions, and larger population-based studies, could facilitate further understanding of the interplay between cognitive impairment, ARHI and frailty in older age. Deficits in both peripheral hearing and central auditory processing (CAP) can contribute to ARHI. Impairments in peripheral hearing and CAP have been linked to accelerated cognitive decline, incident cognitive impairment and AD; moreover, CAP dysfunction is common in mild cognitive impairment (MCI) and AD. Assessment of CAP dysfunction in people with ARHI might, therefore, aid identification of older individuals with increased risk of MCI and AD.

Indexed as

AgingAlzheimer DiseaseDementiaHearing DisordersHumansNeuropsychological TestsRisk Factors

Identifiers

PMID25686757
OpenAlexW2036827115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.