ArticleMedical science monitor : international medical journal of experimental and clinical research2015
Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between the neutrophil-to-lymphocyte ratio and obstructive sleep apnea: a meta-analysis.Scientific reports · 2020Pooled it
- Pooled it
- Impact of Obstructive Sleep Apnea Syndrome on Endothelial Function, Arterial Stiffening, and Serum Inflammatory Markers: An Updated Meta-analysis and Metaregression of 18 Studies.Journal of the American Heart Association · 2015Pooled it
- Dose-response relationship between obstructive sleep apnoea severity and C-reactive protein levels: data from the European Sleep Apnoea Database.ERJ open research · 2026Article
- Usefulness of Blood Biomarkers in Screening Patients with Obstructive Sleep Apnea: Could Albumin Indices and Uric Acid-to-HDL Ratio Be New OSAS Severity Indices?Advances in respiratory medicine · 2025Article
- Reference range of neutrophil-to-lymphocyte ratio in healthy individuals and its predictive value for post-trauma nosocomial infections.Frontiers in cellular and infection microbiology · 2025Article
- Review
- The relationship between the systemic immune-inflammation index and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Sex-Specific Associations Between Leucocyte Measures and Obstructive Sleep Apnea in Han Chinese.Nature and science of sleep · 2024Article
- Serum C-reactive protein level and sleep characteristics in obstructive sleep apnea syndrome comorbid with panic disorder: a preliminary study.BMC psychiatry · 2023Article
- The Role of Hemogram-derived Ratios in COVID-19 Severity Stratification in a Primary Healthcare Facility.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023Article
- The Independent Value of Neutrophil to Lymphocyte Ratio in Gouty Arthritis: A Narrative Review.Journal of inflammation research · 2023Review
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals.Medicina (Kaunas, Lithuania) · 2022Article
- Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2022Article
- The evaluation of serum tryptophan and kynurenine levels in patients with obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2021Article
- Evaluation of Blood Levels of C-Reactive Protein Marker in Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis and Meta-Regression.Life (Basel, Switzerland) · 2021Review
- The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia.Frontiers in cellular and infection microbiology · 2020Article
- Response of Blood Parameters to CPAP Treatment in Patients with Obstructive Sleep Apnea.Noro psikiyatri arsivi · 2019Article
- Hematological indices as simple, inexpensive and practical severity markers of obstructive sleep apnea syndrome: a meta-analysis.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea syndrome (OSAS) is characterized by cyclic episodes of hypoxemia and reoxygenation. It has been suggested that OSAS is associated with chronic inflammation within the microvasculature. This low-grade inflammation may play a role in the pathophysiology of OSAS-related comorbidities. Evaluation of the inflammatory markers may predict the degree of the systemic inflammation and this may be a prognostic factor for future adverse events such as cardiovascular risks. Proinflammatory cytokines have been extensively studied in sleep-disordered breathing. Neutrophil-to-lymphocyte ratio is a recently described indicator of systemic inflammation, but it has not been studied in OSAS patients. In this study we aimed to evaluate the easily measurable parameters of systemic inflammation in these patients. We conducted this study to examine the association among OSAS and C- reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio. MATERIAL AND
methodsOSAS patients who underwent overnight polysomnography were studied retrospectively. They were divided into 4 groups: control, mild, moderate, and severe OSAS patients. Blood test results and inflammatory markers were compared between the groups. One-way ANOVA and Kruskall-Wallis H test were used for statistical analysis.
resultsA total of 147 patients were included in the study. No differences in evaluated inflammatory markers were observed among the 4 groups.
conclusionsEvaluation of the OSAS-related systemic inflammation is not likely to be possible by CRP, ESR, or neutrophil-to-lymphocyte ratio measurements. These markers do not seem to be associated with the degree of the upper airway obstruction.
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