ReviewCancers2015
Proton radiobiology.
Review in Cancers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03561220 (A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer), which is not on this map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
Who cites it
84 citing papers in PubMed.
- Five-year outcomes of partial breast proton beam therapy without lumpectomy for early-stage breast cancer: an interventional prospective study.Breast cancer (Tokyo, Japan) · 2026Article
- Tissue-level RBE determination and normal lung responses along the proton SOBP.Radiation oncology (London, England) · 2026Article
- Disparities in Proton Radiation Utilization for HPV-Associated Oropharyngeal Cancer Following TORS.Head & neck · 2026Article
- Investigation of relative biological effectiveness for protons, carbon and oxygen ion beams by DNA damage calculations in a fractal fibroblast cell geometry.Radiological physics and technology · 2026Article
- Monte Carlo calculations of target fragments from helium and carbon ion interactions with water.Zeitschrift fur medizinische Physik · 2026Article
- Article
- In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy.Clinical and translational radiation oncology · 2026Article
- In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup.Clinical and translational radiation oncology · 2025Article
- Polyacrylic Acid-Coated LaBPharmaceutics · 2025Article
- Current state of proton therapy for tumors of the central nervous system in Spain: physical bases, indications, controversies and perspectives.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy.Nanomaterials (Basel, Switzerland) · 2025Review
- Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons.Pharmaceutics · 2025Review
- Estimating proton beam therapy utilization and Investment in Thailand.Frontiers in public health · 2025Article
- Reirradiation - still navigating uncharted waters?Clinical and translational radiation oncology · 2024Review
- Olaparib enhances sensitization of BRCA-proficient breast cancer cells to x-rays and protons.Breast cancer research and treatment · 2024Article
- DNA damage and repair dependencies of ionising radiation modalities.Bioscience reports · 2023Review
- Preoperative stereotactic radiosurgery as neoadjuvant therapy for resectable brain tumors.Journal of neuro-oncology · 2023Review
- Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2023Article
- Long Term Outcome and Quality of Life of Intracranial Meningioma Patients Treated with Pencil Beam Scanning Proton Therapy.Cancers · 2023Article
- Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model.Communications biology · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assuming a fixed RBE of 1.1 for the whole radiation field. However, data emerging from recent studies suggest that, for several end points of clinical relevance, the biological response is differentially modulated by protons compared to photons. In parallel, research in the field of medical physics highlighted how variations in RBE that are currently neglected might actually result in deposition of significant doses in healthy organs. This seems to be relevant in particular for normal tissues in the entrance region and for organs at risk close behind the tumor. All these aspects will be considered and discussed in this review, highlighting how a re-discussion of the role of a variable RBE in proton therapy might be well-timed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.