ArticleBiomacromolecules2015
Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Enabling adenosine signaling to promote aged fracture healing.NPJ Regenerative medicine · 2025Article
- Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Extracellular adenosine signaling in bone health and disease.Current opinion in pharmacology · 2023Review
- Static and Dynamic Biomaterial Engineering for Cell Modulation.Nanomaterials (Basel, Switzerland) · 2022Review
- Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.Biomaterials · 2021Review
- Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss.Biomaterials · 2021Article
- A dual-ink 3D printing strategy to engineer pre-vascularized bone scaffolds in-vitro.Materials science & engineering. C, Materials for biological applications · 2021Article
- Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells.BMC developmental biology · 2021Article
- Mineralized nanofibrous scaffold promotes phenamil-induced osteoblastic differentiation while mitigating adipogenic differentiation.Journal of tissue engineering and regenerative medicine · 2020Article
- In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss.Science advances · 2019Article
- Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.Biomaterials · 2019Review
- Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.Acta biomaterialia · 2018Article
- Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells.Tissue engineering. Part A · 2018Article
- Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.Current protocols in stem cell biology · 2018Article
- In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Biodegradable mesoporous delivery system for biomineralization precursors.International journal of nanomedicine · 2017Article
- Adenosine A2B receptors play an important role in bone homeostasis.Purinergic signalling · 2016Article
- Hydrogels as Extracellular Matrix Analogs.Gels (Basel, Switzerland) · 2016Review
- Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.Science advances · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stem cell differentiation is determined by a repertoire of signals from its microenvironment, which includes the extracellular matrix (ECM) and soluble cues. The ability of mesenchymal stem cells (MSCs), a common precursor for the skeletal system, to differentiate into osteoblasts and adipocytes in response to their local cues plays an important role in skeletal tissue regeneration and homeostasis. In this study, we investigated whether a bone-specific calcium phosphate (CaP) mineral environment could induce osteogenic differentiation of human MSCs, while inhibiting their adipogenic differentiation, in the presence of adipogenic-inducing medium. We also examined the mechanism through which the mineralized matrix suppresses adipogenesis of hMSCs to promote their osteogenic differentiation. Our results show that hMSCs cultured on mineralized matrices underwent osteogenic differentiation despite being cultured in the presence of adipogenic medium, which indicates the dominance of matrix-based cues of the mineralized matrix in directing osteogenic commitment of stem cells. Furthermore, the mineralized matrix-driven attenuation of adipogenesis was reversed with the inhibition of A2b adenosine receptor (A2bR), implicating a role of adenosine signaling in mineralized environment-mediated inhibition of adipogenesis. Such synthetic matrices with an intrinsic ability to direct differentiation of multipotent adult stem cells toward a targeted phenotype while inhibiting their differentiation into other lineages not only will be a powerful tool in delineating the role of complex microenvironmental cues on stem cell commitment but also will contribute to functional tissue engineering and their translational applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.