Evidence map›Paper›PMID 25686146›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2015

The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana.

M S Kelly, K E Wirth, J Madrigano, K A Feemster, C K Cunningham, T Arscott-Mills, S Boiditswe, S S Shah, R Finalle, A P Steenhoff

Abstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M S KellyBotswana-UPenn Partnership, Gaborone, Botswana; Global Health Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.
K E WirthDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
J MadriganoDepartment of Environmental and Occupational Health, Rutgers School of Public Health, Piscataway, New Jersey, USA.
K A FeemsterGlobal Health Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
C K CunninghamDivision of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.
T Arscott-MillsBotswana-UPenn Partnership, Gaborone, Botswana; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
S BoiditsweBotswana-UPenn Partnership, Gaborone, Botswana.
S S ShahDivisions of Hospital Medicine and Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
R FinalleGlobal Health Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
A P SteenhoffBotswana-UPenn Partnership, Gaborone, Botswana; Global Health Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Institutional Training Grant in Pediatric Infectious DiseaseT32HD060558 · NICHD · DUKE UNIVERSITY · PI CUNNINGHAM, COLEEN K. · 2011 to 2015
$1.0M
NIAID NIH HHS P30 AI045008NIAID NIH HHS P30-AI045008NIAID NIH HHS P30 AI064518NIAID NIH HHS P30-AI064518NICHD NIH HHS T32 HD060558
6 · The paper itself

Abstract

settingTertiary hospital in Gaborone, Botswana.

objectiveTo examine whether exposure to wood smoke worsens outcomes of childhood pneumonia.

designProspective cohort study of children aged 1-23 months meeting clinical criteria for pneumonia. Household use of wood as a cooking fuel was assessed during a face-to-face questionnaire with care givers. We estimated crude and adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for treatment failure at 48 h by household use of wood as a cooking fuel. We assessed for effect modification by age (1-5 vs. 6-23 months) and malnutrition (none vs. moderate vs. severe).

resultsThe median age of the 284 enrolled children was 5.9 months; 17% had moderate or severe malnutrition. Ninety-nine (35%) children failed treatment at 48 h and 17 (6%) died. In multivariable analyses, household use of wood as a cooking fuel increased the risk of treatment failure at 48 h (RR 1.44, 95%CI 1.09-1.92, P = 0.01). This association differed by child nutritional status (P = 0.02), with a detrimental effect observed only among children with no or moderate malnutrition.

conclusionsExposure to wood smoke worsens outcomes for childhood pneumonia. Efforts to prevent exposure to smoke from unprocessed fuels may improve pneumonia outcomes among children.

Indexed as

WoodBotswanaBronchodilator AgentsCookingFemaleHIV InfectionsHumansInfantMaleMalnutritionMultivariate AnalysisPneumoniaPrevalenceProportional Hazards ModelsProspective StudiesSmokeBronchodilator AgentsSmoke

Identifiers

PMID25686146
PMCPMC4352146

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.