ArticleTheScientificWorldJournal2015
Effects of TGF-β1 on OPG/RANKL expression of cementoblasts and osteoblasts are similar without stress but different with mechanical compressive stress.
Article in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Targeting the gut‑bone axis through exercise: A novel approach to osteoporosis prevention and treatment (Review).International journal of molecular medicine · 2026Review
- Frequency-Regulated Repeated Micro-Vibration Promotes Osteoblast Differentiation Through BMP Signaling in MC3T3-E1 Cells.Life (Basel, Switzerland) · 2025Article
- Shengu granules ameliorate ovariectomy-induced osteoporosis by the gut-bone-immune axis.Frontiers in microbiology · 2024Article
- Modulating OPG and TGF-β1 mRNA expression via bioelectrical stimulation.Bone reports · 2021Article
- Platelet-rich fibrin increases the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio in osteoblasts.Experimental and therapeutic medicine · 2019Article
- Long noncoding RNA expression profile of mouse cementoblasts under compressive force.The Angle orthodontist · 2019Article
- Mast Cell Mediators Inhibit Osteoblastic Differentiation and Extracellular Matrix Mineralization.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model.Frontiers in physiology · 2017Article
- Expression and function of osteogenic genes runt-related transcription factor 2 and osterix in orthodontic tooth movement in rats.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to explore the effects of TGF-β1 on regulating activities of cementoblasts and osteoblasts with or without stress. MATERIAL AND
methodsHuman recombinant TGF-β1 was added with different doses. Immunohistochemical test of osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB ligand (RANKL) and Alizarin Red-S staining were conducted. Mechanical compressive stress was obtained by increasing the pressure of gaseous phase. OPG/RANKL expression was detected in both cells through quantitative real-time PCR.
resultsSimilar significant differences (P < 0.05) existed in OPG/RANKL change with increasing concentration of TGF-β1 without mechanical stress for cementoblasts and osteoblasts. However, under 3 h stress, OPG increased and RANKL decreased significantly (P < 0.01) but with similar OPG/RANKL change. Moreover, under 24 h stress, OPG change exhibited no difference (P > 0.05), but RANKL decreased significantly (P < 0.01) at 10 and 100 ng/mL TGF-β1 in cementoblasts. In osteoblasts, OPG increased significantly (P < 0.01) at 10 and 100 ng/mL, whereas RANKL decreased with statistical difference (P < 0.05) at 1 and 10 ng/mL.
conclusionsThe effects of TGF-β1 on OPG/RANKL expression of cementoblasts and osteoblasts are similar even without mechanical stress. However, these effects are different under mechanical compressive stress.
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