Evidence map›Paper›PMID 25685845›Full record

ArticleTheScientificWorldJournal2015

Evidence for negative effects of elevated intra-abdominal pressure on pulmonary mechanics and oxidative stress.

I Davarcı, M Karcıoğlu, K Tuzcu, K İnanoğlu, T D Yetim, S Motor, K T Ulutaş, R Yüksel

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02600481 (Comparison of the Impacts of Prolonged Low-pressure and Standard-pressure Pneumoperitoneum on Myocardial and Pulmonary Injuries After Robot-assisted Surgery in the Trendelenburg Position), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02600481 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Comparison of the Impacts of Prolonged Low-pressure and Standard-pressure Pneumoperitoneum on Myocardial and Pulmonary Injuries After Robot-assisted Surgery in the Trendelenburg Position: a Bi-center, Randomized Controlled Trial

TypeinterventionalSponsorHuadong HospitalRan2016 to 2018Enrolled280ConditionsProstatic Neoplasms, Urinary Bladder NeoplasmsArmslow-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Risk Factors for Severe Complications After Laparoscopic Surgery for T3 or T4 Rectal Cancer for Chinese Patients: Experience from a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

I DavarcıDepartment of Anesthesiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
M KarcıoğluDepartment of Anesthesiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
K TuzcuDepartment of Anesthesiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
K İnanoğluDepartment of Anesthesiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
T D YetimDepartment of Thoracic Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
S MotorDepartment of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
K T UlutaşDepartment of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
R YükselDepartment of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Mustafa Kemal University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effects of pneumoperitoneum on lung mechanics, end-tidal CO2 (ETCO2), arterial blood gases (ABG), and oxidative stress markers in blood and bronchoalveolar lavage fluid (BALF) during laparoscopic cholecystectomy (LC) by using lung-protective ventilation strategy. MATERIALS AND

methodsForty-six patients undergoing LC and abdominal wall hernia (AWH) surgery were assigned into 2 groups. Measurements and blood samples were obtained before, during pneumoperitoneum, and at the end of surgery. BALF samples were obtained after anesthesia induction and at the end of surgery.

resultsPeak inspiratory pressure, ETCO2, and pCO2 values at the 30th minute were significantly increased, while there was a significant decrease in dynamic lung compliance, pH, and pO2 values in LC group. In BALF samples, total oxidant status (TOS), arylesterase, paraoxonase, and malondialdehyde levels were significantly increased; the glutathione peroxidase levels were significantly decreased in LC group. The serum levels of TOS and paraoxonase were significantly higher at the end of surgery in LC group. In addition, arylesterase level in the 30th minute was increased compared to baseline. Serum paraoxonase level at the end of surgery was significantly increased when compared to AWH group.

conclusionsOur study showed negative effects of pneumoperitoneum in both lung and systemic levels despite lung-protective ventilation strategy.

Indexed as

AdultAryldialkylphosphataseBlood Gas AnalysisBronchoalveolar Lavage FluidCarboxylic Ester HydrolasesCholecystectomy, LaparoscopicFemaleGlutathione PeroxidaseHumansMaleMalondialdehydeOxidative StressPneumoperitoneumProspective StudiesRespiratory MechanicsAryldialkylphosphatasearylesteraseCarboxylic Ester HydrolasesGlutathione PeroxidaseMalondialdehyde

Identifiers

PMID25685845
PMCPMC4320804
OpenAlexW2079952031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.