SynthesisBioMed research international2015
Integrating retrogenesis theory to Alzheimer's disease pathology: insight from DTI-TBSS investigation of the white matter microstructural integrity.
Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes.Alzheimer's research & therapy · 2025Article
- The Implementation of Infant Anoesis and Adult Autonoesis in the Retrogenesis and Staging System of the Neurocognitive Disorders: A Proposal for a Multidimensional Person-Centered Model.Geriatrics (Basel, Switzerland) · 2025Review
- Article
- Diffusion Tensor Imaging in Parenchymal Neuro-Behçet's Disease.Noro psikiyatri arsivi · 2024Article
- White matter microstructure changes in adults with major depressive disorder: evidence from diffusion magnetic resonance imaging.BJPsych open · 2023Article
- Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023Article
- Fornix degeneration in risk factors of Alzheimer's disease, possible trigger of cognitive decline.Cerebral circulation - cognition and behavior · 2023Review
- Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study.Frontiers in aging neuroscience · 2023Article
- Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance.ACS chemical neuroscience · 2022Article
- White matter pathology in alzheimer's transgenic mice with chronic exposure to low-level ambient fine particulate matter.Particle and fibre toxicology · 2022Article
- A multimodal neuroimaging study of brain abnormalities and clinical correlates in post treatment Lyme disease.PloS one · 2022Article
- Article
- Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer's disease.Scientific reports · 2021Article
- White Matter Abnormalities in Patients With Typhoon-Related Posttraumatic Stress Disorder.Frontiers in human neuroscience · 2021Article
- Alterations and Associations Between Magnetic Susceptibility of the Basal Ganglia and Diffusion Properties in Alzheimer's Disease.Frontiers in neuroscience · 2021Article
- Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities.Frontiers in neurology · 2021Review
- Analysis of Age-Related White Matter Microstructures Based on Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2021Article
- Long Longitudinal Tract Lesion Contributes to the Progression of Alzheimer's Disease.Frontiers in neurology · 2020Article
- Unsuspected Involvement of Spinal Cord in Alzheimer Disease.Frontiers in cellular neuroscience · 2020Article
- White matter and its relationship with cognition in subjective cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microstructural abnormalities in white matter (WM) are often reported in Alzheimer's disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.
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