Trial reportBioMed research international2015
Neural and nonneural contributions to wrist rigidity in Parkinson's disease: an explorative study using the NeuroFlexor.
Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Quantitative Measurement of Rigidity in Parkinson´s Disease: A Systematic Review.Sensors (Basel, Switzerland) · 2020Pooled it
- Speed Matters: Challenging the Notion of Velocity-Independent Rigidity Using Technological Devices in People with Parkinson's Disease: A Systematic Review.Neurology international · 2025Review
- Article
- Rigidity in Parkinson's Disease: The Objective Effect of Levodopa.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions.Metabolic brain disease · 2024Review
- Rigidity in Parkinson's disease: evidence from biomechanical and neurophysiological measures.Brain : a journal of neurology · 2023Article
- The Effects of Extracorporeal Shock Wave Therapy on Spastic Muscle of the Wrist Joint in Stroke Survivors: Evidence From Neuromechanical Analysis.Frontiers in neuroscience · 2020Article
- Neuromechanical Assessment of Activated vs. Resting Leg Rigidity Using the Pendulum Test Is Associated With a Fall History in People With Parkinson's Disease.Frontiers in human neuroscience · 2020Article
- Alterations of Elastic Property of Spastic Muscle With Its Joint Resistance Evaluated From Shear Wave Elastography and Biomechanical Model.Frontiers in neurology · 2019Article
- What If Low Back Pain Is the Most Prevalent Parkinsonism in the World?Frontiers in neurology · 2018Article
- Quantification of neural reflex and muscular intrinsic contributions to parkinsonian rigidity.Experimental brain research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe NeuroFlexor is a novel method incorporating a biomechanical model for the measurement of neural and nonneural contributions to resistance induced by passive stretch. In this study, we used the NeuroFlexor method to explore components of passive movement resistance in the wrist and finger muscles in subjects with Parkinson's disease (PD).
methodsA cross-sectional comparison was performed in twenty-five subjects with PD with clinically identified rigidity and 14 controls. Neural (NC), elastic (EC), and viscous (VC) components of the resistance to passive extension of the wrist were calculated using the NeuroFlexor. Measurements were repeated during a contralateral activation maneuver.
resultsPD subjects showed greater total resistance (P < 0.001) and NC (P = 0.002) compared to controls. EC and VC did not differ significantly between groups. Contralateral activation maneuver resulted in increased NC in the PD group but this increase was due to increased resting tension. Total resistance and NC correlated with clinical ratings of rigidity and with bradykinesia.
conclusionsThe findings suggest that stretch induced reflex activity, but not nonneural resistance, is the major contributor to rigidity in wrist muscles in PD. The NeuroFlexor is a potentially valuable clinical and research tool for quantification of rigidity.
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