Evidence map›Paper›PMID 25685762›Full record

ReviewWorld journal of clinical cases2015

Review on microbiota and effectiveness of probiotics use in older.

Mariangela Rondanelli, Attilio Giacosa, Milena Anna Faliva, Simone Perna, Francesca Allieri, Anna Maria Castellazzi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of clinical cases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Randomized study ofWorld journal of gastroenterology · 2025
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  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Influence ofFoods (Basel, Switzerland) · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Inflammation and aging: signaling pathways and intervention therapies.Signal transduction and targeted therapy · 2023
    Review
  19. Influence of the Mediterranean Diet on Healthy Aging.International journal of molecular sciences · 2023
    Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 3 countries.

Mariangela RondanelliMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Attilio GiacosaMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Milena Anna FalivaMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Simone PernaMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Francesca AllieriMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Anna Maria CastellazziMariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy.
Azienda di Servizi alla Persona di Pavia (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present systematic review is to summarize the existing knowledge about the human microbiota in the elderly and the effects of probiotics in elderly population. The elderly subjects, compared to adult population, show a reduction in the diversity of the microbiota, characterized by a large interindividual variability, with lower numbers of Firmicutes, Bifidobacteria, Clostridium cluster XIV, Faecalibacterium Prausnitzii, Blautia coccoides-Eubacterium rectal and higher presence of Enterobacteriaceae and Bacteroidetes. These differences of the intestinal microbiota of the elderly may not necessarily be caused by aging, but they could be associated with the decline of the general state of health with malnutrition and with increased need for medication, such as antibiotics and nonsteroidal anti-inflammatory drugs, situations that occur frequently in the elderly. Differences have been demonstrated in the composition of the microbiota between healthy elderly subjects and hospitalized or institutionalized elderly subjects. These findings which further indicates that the living conditions, health status, nutrition and drugs have a significant effect on the composition of the microbiota. According to the available knowledge, the use of probiotics is safe and could represent an useful intervention to prevent or treat antibiotic-associated diarrhea, in addition to reducing the severity of symptoms, other than to help the management of constipation.

Indexed as

Antibiotic-associated diarrheaConstipationElderlyMicrobiotaProbiotics

Identifiers

PMID25685762
PMCPMC4317609
OpenAlexW2325821426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.