Evidence map›Paper›PMID 25685727›Full record

ArticleWorld journal of critical care medicine2015

Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care.

Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02617199 phase2 / phase3unknown statusnot on this map

Epidural Anesthesia as an Alternative for Management in Acute Pancreatitis, a Randomised Clinical Trial

TypeinterventionalSponsorHospital General Naval de Alta Especialidad - Escuela Medico NavalRan2015 to 2017Enrolled60ConditionsAcute PancreatitisArmsEpidural anesthesia, intravenous analgesia
NCT03219398 nacompletednot on this mapstarted 2017, after this paper: background citation

Comparison Effect Between Lower Pressure and Standard Pressure Pneumoperitoneum on Sign of Acute Systemic Inflammation, Endothelial Injury, and Acute Kidney Injury: A Randomized Clinical Trial in Living Donor Laparoscopic Nephrectomy

TypeinterventionalSponsorIndonesia UniversityRan2017 to 2018Enrolled44ConditionsHealthyArmsPneumoperitoneum pressure
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Epidurals in esophagectomy: end of an era?Journal of thoracic disease · 2026
    Article
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  3. Observational
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonio SiniscalchiAntonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Lorenzo GamberiniAntonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Cristiana LaiciAntonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Tommaso BardiAntonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Stefano FaenzaAntonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi, Stefano Faenza, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
University of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the currently available evidence on thoracic epidural anesthesia effects on splanchnic macro and microcirculation, in physiologic and pathologic conditions.

methodsA PubMed search was conducted using the MeSH database. Anesthesia, Epidural was always the first MeSH heading and was combined by boolean operator AND with the following headings: Circulation, Splanchnic; Intestines; Pancreas and Pancreatitis; Liver Function Tests. EMBASE, Cochrane library, ClinicalTrials.gov and clinicaltrialsregister.eu were also searched using the same terms.

resultsTwenty-seven relevant studies and four ongoing trials were found. The data regarding the effects of epidural anesthesia on splanchnic perfusion are conflicting. The studies focusing on regional macro-hemodynamics in healthy animals and humans undergoing elective surgery, demonstrated no influence or worsening of regional perfusion in patients receiving thoracic epidural anesthesia (TEA). On the other hand most of the studies focusing on micro-hemodynamics, especially in pathologic low flow conditions, suggested that TEA could foster microcirculation.

conclusionThe available studies in this field are heterogeneous and the results conflicting, thus it is difficult to draw decisive conclusions. However there is increasing evidence deriving from animal studies, that thoracic epidural blockade could have an important role in modifying tissue microperfusion and protecting microcirculatory weak units from ischemic damage, regardless of the effects on macro-hemodynamics.

Indexed as

AnesthesiaCirculationEpiduralIntestineLiver function testsMicrocirculationPancreatitisSplanchnic

Identifiers

PMID25685727
PMCPMC4326768
OpenAlexW1964609759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.