ArticleNeuroImage. Clinical2015
Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies.Journal of biomedical science · 2026Article
- Longitudinal biomarkers in dementia with Lewy bodies: A systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2026Review
- A Unified Continuous Staging Framework for Alzheimer's Disease and Lewy Body Dementia via Hierarchical Anatomical Features.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2025Article
- Magnitude and kinetics of a set of neuroanatomic volume and thickness together with white matter hyperintensity is definitive of cognitive status and brain age.Translational psychiatry · 2024Article
- Increased Cortical Thickness in Alzheimer's Disease.Annals of neurology · 2024Article
- The use of neuroimaging techniques in the early and differential diagnosis of dementia.Molecular psychiatry · 2023Review
- Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration.Brain communications · 2022Article
- The latent factor structure underlying regional brain volume change and its relation to cognitive change in older adults.Neuropsychology · 2021Article
- A Predictive and Preventive Model for Onset of Alzheimer's Disease.Frontiers in public health · 2021Article
- Long-standing multiple sclerosis neurodegeneration: volumetric magnetic resonance imaging comparison to Parkinson's disease, mild cognitive impairment, Alzheimer's disease, and elderly healthy controls.Neurobiology of aging · 2020Article
- Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia.The Australian and New Zealand journal of psychiatry · 2020Article
- Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change.Reviews in the neurosciences · 2019Review
- Dysfunctional brain dynamics and their origin in Lewy body dementia.Brain : a journal of neurology · 2019Article
- The association between brain volume, cortical brain infarcts, and physical frailty.Neurobiology of aging · 2018Article
- Biomarkers in Alzheimer's, Frontotemporal, Lewy Body, and Vascular Dementias.Focus (American Psychiatric Publishing) · 2018Review
- Automatic normative quantification of brain tissue volume to support the diagnosis of dementia: A clinical evaluation of diagnostic accuracy.NeuroImage. Clinical · 2018Article
- Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease.Neurobiology of aging · 2017Article
- Whole brain analysis of postmortem density changes of grey and white matter on computed tomography by statistical parametric mapping.European radiology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivePercent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer's disease (AD). However, the utility of PBVC in the differential diagnosis of dementia remains to be established. We compared PBVC in AD and dementia with Lewy bodies (DLB), and investigated associations with clinical measures.
methods72 participants (14 DLBs, 25 ADs, and 33 healthy controls (HCs)) underwent clinical assessment and 3 Tesla T1-weighted MRI at baseline and repeated at 12 months. We used FSL-SIENA to estimate PBVC for each subject. Voxelwise analyses and ANCOVA compared PBVC between DLB and AD, while correlational tests examined associations of PBVC with clinical measures.
resultsAD had significantly greater atrophy over 1 year (1.8%) compared to DLB (1.0%; p = 0.01) and HC (0.9%; p < 0.01) in widespread regions of the brain including periventricular areas. PBVC was not significantly different between DLB and HC (p = 0.95). There were no differences in cognitive decline between DLB and AD. In the combined dementia group (AD and DLB), younger age was associated with higher atrophy rates (r = 0.49, p < 0.01).
conclusionsAD showed a faster rate of global brain atrophy compared to DLB, which had similar rates of atrophy to HC. Among dementia subjects, younger age was associated with accelerated atrophy, reflecting more aggressive disease in younger people. PBVC could aid in differentiating between DLB and AD, however its utility as an outcome marker in DLB is limited.
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