ArticleNeuroImage. Clinical2015
Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Metabolomics in Depression: What We Learn from Preclinical and Clinical Evidences.Molecular neurobiology · 2025Pooled it
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Gray matter structural alterations in first-episode drug-naïve adolescents with major depressive disorder: a comprehensive morphological analysis study.Psychological medicine · 2025Article
- Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder.Frontiers in psychiatry · 2024Article
- Identification of structural brain alterations in adolescents with depressive symptomatology.Brain research bulletin · 2023Article
- Identification and discovery of imaging genetic patterns using fusion self-expressive network in major depressive disorder.Frontiers in neuroscience · 2023Article
- Incorporating multi-stage diagnosis status to mine associations between genetic risk variants and the multi-modality phenotype network in major depressive disorder.Frontiers in psychiatry · 2023Article
- Treatment Response Prediction for Major Depressive Disorder PatientsFrontiers in computational neuroscience · 2022Article
- Individualized diagnosis of major depressive disorder via multivariate pattern analysis of thalamic sMRI features.BMC psychiatry · 2021Article
- Brain Volume Abnormalities in Youth at High Risk for Depression: Adolescent Brain and Cognitive Development Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Adolescent depression and brain development: evidence from voxel-based morphometryJournal of psychiatry & neuroscience : JPN · 2019Article
- Longitudinal brain volume changes in major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Impaired Frontal-Limbic White Matter Maturation in Children at Risk for Major Depression.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Injection of Anti-proBDNF in Anterior Cingulate Cortex (ACC) Reverses Chronic Stress-Induced Adverse Mood Behaviors in Mice.Neurotoxicity research · 2017Article
- Molecular, Functional, and Structural Imaging of Major Depressive Disorder.Neuroscience bulletin · 2016Review
- Functional MRI of emotional memory in adolescent depression.Developmental cognitive neuroscience · 2016Article
- Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment.Frontiers in systems neuroscience · 2016Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThere is little understanding of the neural system abnormalities subserving adolescent major depressive disorder (MDD). In a cross-sectional study we compare currently unipolar depressed with healthy adolescents to determine if group differences in grey matter volume (GMV) were influenced by age and illness severity.
methodStructural neuroimaging was performed on 109 adolescents with current MDD and 36 healthy controls, matched for age, gender, and handedness. GMV differences were examined within the anterior cingulate cortex (ACC) and across the whole-brain. The effects of age and self-reported depressive symptoms were also examined in regions showing significant main or interaction effects.
resultsWhole-brain voxel based morphometry revealed no significant group differences. At the whole-brain level, both groups showed a main effect of age on GMV, although this effect was more pronounced in controls. Significant group-by-age interactions were noted: A significant regional group-by-age interaction was observed in the ACC. GMV in the ACC showed patterns of age-related differences that were dissimilar between adolescents with MDD and healthy controls. GMV in the thalamus showed an opposite pattern of age-related differences in adolescent patients compared to healthy controls. In patients, GMV in the thalamus, but not the ACC, was inversely related with self-reported depressive symptoms.
conclusionsThe depressed adolescent brain shows dissimilar age-related and symptom-sensitive patterns of GMV differences compared with controls. The thalamus and ACC may comprise neural markers for detecting these effects in youth. Further investigations therefore need to take both age and level of current symptoms into account when disaggregating antecedent neural vulnerabilities for MDD from the effects of MDD on the developing brain.
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