ArticleMolecular metabolism2015
A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health.
Article in Molecular metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- The coordinated actions of metformin in the intestine and liver improves hyperglycemia.Cell reports · 2026Article
- Obesity and the gut microbiota: implications of neuroendocrine and immune signaling.The FEBS journal · 2025Review
- Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits.Molecular metabolism · 2024Article
- Article
- Exploring the effects of dietary inulin in rainbow trout fed a high-starch, 100% plant-based diet.Journal of animal science and biotechnology · 2024Article
- Functional and molecular profiling of fasted piglets reveals decreased energy metabolic function and cell proliferation in the small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Oligofructose alone and in combination with 2'fucosyllactose induces physiologically relevant changes in γ-aminobutyric acid and organic acid production compared to sole 2'fucosyllactose supplementation: an in vitro study.FEMS microbiology ecology · 2023Article
- Neural innervation in adipose tissue, gut, pancreas, and liver.Life metabolism · 2023Review
- Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution.Nature reviews. Gastroenterology & hepatology · 2023Review
- Journey of the Probiotic Bacteria: Survival of the Fittest.Microorganisms · 2022Review
- Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability.Nutrients · 2022Review
- Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease.BMC medicine · 2022Article
- Metabolic Action of Metformin.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.Frontiers in nutrition · 2022Article
- Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish.Frontiers in nutrition · 2022Article
- Fructose in the kidney: from physiology to pathology.Kidney research and clinical practice · 2021Article
- Cachexia as Evidence of the Mechanisms of Resistance and Tolerance during the Evolution of Cancer Disease.International journal of molecular sciences · 2021Review
- Metformin and Systemic Metabolism.Trends in pharmacological sciences · 2020Review
- The Controversial Role of Human Gut Lachnospiraceae.Microorganisms · 2020Review
- Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.Molecular metabolism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCertain nutrients positively regulate energy homeostasis via intestinal gluconeogenesis (IGN). The objective of this study was to evaluate the impact of a deficient IGN in glucose control independently of nutritional environment.
methodsWe used mice deficient in the intestine glucose-6 phosphatase catalytic unit, the key enzyme of IGN (I-G6pc (-/-) mice). We evaluated a number of parameters involved in energy homeostasis, including insulin sensitivity (hyperinsulinemic euglycaemic clamp), the pancreatic function (insulin secretion in vivo and in isolated islets) and the hypothalamic homeostatic function (leptin sensitivity).
resultsIntestinal-G6pc (-/-) mice exhibit slight fasting hyperglycaemia and hyperinsulinemia, glucose intolerance, insulin resistance and a deteriorated pancreatic function, despite normal diet with no change in body weight. These defects evoking type 2 diabetes (T2D) derive from the basal activation of the sympathetic nervous system (SNS). They are corrected by treatment with an inhibitor of α-2 adrenergic receptors. Deregulation in a key target of IGN, the homeostatic hypothalamic function (highlighted here through leptin resistance) is a mechanistic link. Hence the leptin resistance and metabolic disorders in I-G6pc (-/-) mice are corrected by rescuing IGN by portal glucose infusion. Finally, I-G6pc (-/-) mice develop the hyperglycaemia characteristic of T2D more rapidly under high fat/high sucrose diet.
conclusionsIntestinal gluconeogenesis is a mandatory function for the healthy neural control of glucose homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.