ArticleArthroscopy techniques2014
Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis.
Article in Arthroscopy techniques, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03790189 (Subchondral and Intra-articular Application of Bone Marrow Concentrate as a Treatment Strategy for Knee Unicompartmental Osteoarthritis), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subchondral and Intra-articular Application of Bone Marrow Concentrate as a Treatment Strategy for Knee Unicompartmental Osteoarthritis (OA): a Pilot Trial
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- Bone marrow concentrate injections for the treatment of osteoarthritis: evidence from preclinical findings to the clinical application.International orthopaedics · 2021Pooled it
- Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis.Pain medicine (Malden, Mass.) · 2019Pooled it
- Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis.Clinical rheumatology · 2018Trial
- Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study.BioMed research international · 2016Trial
- Beyond Cartilage Regeneration: Targeting the Subchondral Bone with Extracorporeal Shock Wave Therapy and Regenerative Medicine in Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2026Review
- Intraosseous platelet-rich plasma for osteoarthritis: a comprehensive review.EFORT open reviews · 2026Review
- Subchondral Knee Injections: A Comprehensive Systematic Review of Current Clinical Outcomes, Safety, and Arthroplasty Delay.Cartilage · 2026Article
- Influence of Tendon Location on the Clinical Response to Platelet-Rich Plasma: A Prospective Cohort Study of Rotator Cuff, Achilles and Patellar Tendinopathies.Journal of clinical medicine · 2026Article
- Intra-articular and intra-osseous expanded adipose-derived stromal cell injections for knee osteoarthritis-related bone marrow lesions yield promising outcomes: Preliminary results in 16 athletes.Journal of experimental orthopaedics · 2026Article
- Plasma Rich in Growth Factors (PRGF) Versus Saline Intraosseous Infiltrations Combined with Intra-Articular PRGF in Severe Knee Osteoarthritis: A Prospective Double-Blind Multicentric Randomized Controlled Trial with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study.Journal of clinical medicine · 2023Article
- Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: Histological assessment.Frontiers in veterinary science · 2023Article
- Office-Based Intraosseous Infiltrations of PRGF in Knee Osteoarthritis: Description of Technique.Arthroscopy techniques · 2022Article
- Real-world evidence to assess the effectiveness of platelet-rich plasma in the treatment of knee degenerative pathology: a prospective observational study.Therapeutic advances in musculoskeletal disease · 2022Article
- Treating Full Depth Cartilage Defects with Intraosseous Infiltration of Plasma Rich in Growth Factors: An Experimental Study in Rabbits.Cartilage · 2021Article
- Intraosseous Injections Are Safe And Effective in Knee Osteoarthritis: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2021Review
- Role of Scaffolds, Subchondral, Intra-Articular Injections of Fresh Autologous Bone Marrow Concentrate Regenerative Cells in Treating Human Knee Cartilage Lesions: Different Approaches and Different Results.International journal of molecular sciences · 2021Review
- Platelet-rich plasma injections delay the need for knee arthroplasty: a retrospective study and survival analysis.International orthopaedics · 2021Article
- Optimising proliferation and migration of mesenchymal stem cells using platelet products: A rational approach to bone regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a new technique of platelet-rich plasma (PRP) infiltration for the treatment of severe knee osteoarthritis. PRP intra-articular infiltration is a promising treatment for knee osteoarthritis, but it still has some limitations in high-degree osteoarthritis. Diagnosis of osteoarthritis is based on clinical and radiographic findings, and patients with grade III or IV knee tibiofemoral osteoarthritis based on the Ahlbäck scale are considered candidates for this technique. The technique consists of performing intraosseous infiltration of PRP into the subchondral bone, which acts on this tissue and consequently on cartilage-bone communication. Although the intraosseous injection hinders the conventional knee intra-articular infiltration, it allows an extension of the range of action of the PRP, which acts directly on the subchondral bone, which is involved in the progression of osteoarthritis. Thus this technique involves a new administration of PRP that can delay knee arthroplasty; moreover, it can be applied for not only severe osteoarthritis but also other pathologies in which the subchondral bone is critical in the etiology, such as necrosis and osteochondral lesions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.