Evidence map›Paper›PMID 25685596›Full record

ReviewStroke research and treatment2015

Protocol variations and six-minute walk test performance in stroke survivors: a systematic review with meta-analysis.

A Dunn, D L Marsden, E Nugent, P Van Vliet, N J Spratt, J Attia, R Callister

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Stroke research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05549141 (Cardiovascular and Metabolic Effects of Treadmill Gait Training Associated With Functional Electrical Stimulation in Individuals Post-brain Vascular Accident), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05549141 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Cardiovascular and Metabolic Effects of Treadmill Gait Training Associated With Functional Electrical Stimulation in Individuals Post-brain Vascular Accident

TypeinterventionalSponsorUniversity of Sao PauloRan2022 to 2023Enrolled28ConditionsStrokeArmstreadmill gait training with gait facilitators, treadmill gait training not-associated with gait facilitators
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Measuring Physical Function Capacity in Persons With Haemophilia: A Systematic Review of Performance-Based Methods.Haemophilia : the official journal of the World Federation of Hemophilia · 2025
    Pooled it
  2. Reliability of the six-minute walk test in individuals with stroke: systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  3. Pooled it
  4. Effect ofInternational journal of medical sciences · 2026
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  13. Home-Based Gait Interventions for Adults with Stroke: A Scoping Review.Archives of rehabilitation research and clinical translation · 2025
    Review
  14. Article
  15. Review
  16. Multi-Modal Sensing for Propulsion Estimation in People Post-Stroke Across Speeds.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A DunnUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
D L MarsdenUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia ; Hunter New England Local Health District, New Lambton Heights, NSW 2305, Australia.
E NugentUniversity of Newcastle, Callaghan, NSW 2308, Australia.
P Van VlietUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
N J SprattUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia ; Hunter New England Local Health District, New Lambton Heights, NSW 2305, Australia.
J AttiaUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
R CallisterUniversity of Newcastle, Callaghan, NSW 2308, Australia ; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
University of Newcastle Australia · AUHunter Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. To investigate the use of the six-minute walk test (6MWT) for stroke survivors, including adherence to 6MWT protocol guidelines and distances achieved. Methods. A systematic search was conducted from inception to March 2014. Included studies reported a baseline (intervention studies) or first instance (observational studies) measure for the 6MWT performed by stroke survivors regardless of time after stroke.  Results. Of 127 studies (participants n = 6,012) that met the inclusion criteria, 64 were also suitable for meta-analysis. Only 25 studies made reference to the American Thoracic Society (ATS) standards for the 6MWT, and 28 reported using the protocol standard 30 m walkway. Thirty-nine studies modified the protocol walkway, while 60 studies did not specify the walkway used. On average, stroke survivors walked 284 ± 107 m during the 6MWT, which is substantially less than healthy age-matched individuals. The meta-analysis identified that changes to the ATS protocol walkway are associated with reductions in walking distances achieved. Conclusion. The 6MWT is now widely used in stroke studies. The distances achieved by stroke patients indicate substantially compromised walking ability. Variations to the standard 30 m walkway for the 6MWT are common and caution should be used when comparing the values achieved from studies using different walkway lengths.

Identifiers

PMID25685596
PMCPMC4320847
OpenAlexW2015036088

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.