Evidence map›Paper›PMID 25685481›Full record

ReviewJournal of advanced research2014

Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review.

Badr M Ibrahim, Abdel A Abdel-Rahman

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  3. CBNaunyn-Schmiedeberg's archives of pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Badr M IbrahimDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Abdel A Abdel-RahmanDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
East Carolina University · US

Funding

Negative Impact of Alcohol on Cardiovascular NeurobiologyR01AA007839 · NIAAA · EAST CAROLINA UNIVERSITY · PI ABDEL-RAHMAN, ABDEL A · 1995 to 2011
$3.7M
NIAAA NIH HHS R01 AA007839
6 · The paper itself

Abstract

Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB1R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms. The current review focuses on the rostral ventrolateral medulla (RVLM) as the primary brainstem nucleus implicated in CB1R-evoked pressor response.

Indexed as

CannabinoidsCardiovascularERK1/2nNOSPI3KRVLM

Identifiers

PMID25685481
PMCPMC4294710
OpenAlexW2046914103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.