Evidence map›Paper›PMID 25685295›Full record

ReviewKorean journal of urology2015

Clinically relevant genetic characterization of prostate tumors: how close are we to the goal?

Yuri Tolkach, Florian Imkamp, Konstantin Godin, Hendrik Van Poppel

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Korean journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yuri TolkachUrology and Urologic Oncology Clinic, Hannover Medical School, Hannover, Germany.
Florian ImkampUrology and Urologic Oncology Clinic, Hannover Medical School, Hannover, Germany.
Konstantin GodinCatholic Clinic Koblenz-Montabaur, Montabaur, Germany.
Hendrik Van PoppelDepartment of Urology, University Hospitals of Catholic University of Leuven, Leuven, Belgium.
Medizinische Hochschule Hannover · DEKatholisches Klinikum Koblenz · DEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial efforts are being made in research on the molecular genetic characterization of prostate cancer. The number of fundamental research programs in prostate cancer molecular biology and genetics is overwhelming. However, a significant gap appears to exist between the huge number of studies on the genetic characterization of prostate cancer, which often have limited translation into clinical practice or simply were not conceived to be so translated, and clinical practice. From a clinical point of view, this balance should be urgently shifted towards rapid translation into urological practice. However, prostate cancer is characterized by prominent genetic heterogeneity, which could be a very difficult barrier to overcome. In this review, we discuss the possible clinical applications of scientific data from fundamental studies of prostate cancer genetics, the main problems with the translation of these data to clinics, and future perspectives.

Indexed as

Biomarkers, TumorEpigenesis, GeneticGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGoalsHumansMaleProstatic NeoplasmsTranscriptomeBiomarkers, TumorBiological markersMolecular biologyProstate neoplasmsTranslations

Identifiers

PMID25685295
PMCPMC4325124
OpenAlexW2048241841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.