ReviewWorld journal of diabetes2015
Adiponectin: Probe of the molecular paradigm associating diabetes and obesity.
Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus: A Meta-Analysis.Medicine · 2017Pooled it
- Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human.Aging · 2016Pooled it
- Effect of Almond Supplementation on Glycemia and Cardiovascular Risk Factors in Asian Indians in North India with Type 2 Diabetes Mellitus: A 24-Week Study.Metabolic syndrome and related disorders · 2017Trial
- Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial.Cardiovascular diabetology · 2016Trial
- Pathophysiological modulations by Trimad, a polyherbal formulation, in a rat model of high-fat diet-induced obesity.Journal of Ayurveda and integrative medicine · 2026Article
- Serum cortisol and AdipoR2 rs12342 were involved in the correlation between stress and serum cholesterol in a gender-specific manner.Metabolic brain disease · 2025Article
- Elevated serum METRNL levels in children with obesity and its association with insulin resistance.European journal of pediatrics · 2025Article
- Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored.Biochemistry · 2025Review
- The Role of Adiponectin andGenes · 2025Review
- Association ofGenes · 2024Article
- Reevaluating Adiponectin's impact on obesity hypertension: a Chinese case-control study.BMC cardiovascular disorders · 2024Article
- Plasma adiponectin/leptin ratio associates with subcutaneous abdominal and omental adipose tissue characteristics in women.BMC endocrine disorders · 2024Article
- Adipo-oncology: adipocyte-derived factors govern engraftment, survival, and progression of metastatic cancers.Cell communication and signaling : CCS · 2024Review
- A cross-sectional study in adiponectin, glucose metabolism, and body composition in cystic fibrosis.Frontiers in endocrinology · 2024Article
- An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure.Journal of obesity & metabolic syndrome · 2023Review
- Relationship between adiponectin and blood pressure in obese Latino adolescent boys with a family history of type 2 diabetes.BMC pediatrics · 2023Article
- Anthropometric measurements and their association with endothelial function and arterial stiffness of eutrophic individuals and with overweight.Archives of endocrinology and metabolism · 2023Article
- RNA Sequencing (RNA-Seq) Analysis Reveals Liver Lipid Metabolism Divergent Adaptive Response to Low- and High-Salinity Stress in Spotted Scat (Animals : an open access journal from MDPI · 2023Article
- Role of Adiponectin in Cardiovascular Diseases Related to Glucose and Lipid Metabolism Disorders.International journal of molecular sciences · 2022Review
- Genetic and Functional Effects of Adiponectin in Type 2 Diabetes Mellitus Development.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes is an emerging health challenge all over the world as a result of urbanization, high prevalence of obesity, sedentary lifestyle and other stress related factors compounded with the genetic prevalence. The health consequences and economic burden of the obesity and related diabetes mellitus epidemic are enormous. Different signaling molecules secreted by adipocytes have been implicated in the development of obesity and associated insulin resistance in type 2 diabetes. Human adiponectin, a 244-amino acid collagen-like protein is solely secreted by adipocytes and acts as a hormone with anti-inflammatory and insulin-sensitizing properties. Adiponectin secretion, in contrast to secretion of other adipokines, is paradoxically decreased in obesity which may be attributable to inhibition of adiponectin gene transcription. There are several mechanisms through which adiponectin may decrease the risk of type 2 diabetes, including suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in skeletal muscle, and stimulation of insulin secretion. To date, no systematic review has been conducted that evaluate the potential importance of adiponectin metabolism in insulin resistance. In this review attempt has been made to explore the relevance of adiponectin metabolism for the development of diabetes mellitus. This article also identifies this novel target for prospective therapeutic research aiming successful management of diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.