ReviewWorld journal of diabetes2015
Causative anti-diabetic drugs and the underlying clinical factors for hypoglycemia in patients with diabetes.
Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Cognitive Changes Among Patients over 65 Years of Age in a Rural Area-The Preliminary Report of Protective and Predisposing Factors.Neurology international · 2025Article
- Dementia in Diabetes: The Role of Hypoglycemia.International journal of molecular sciences · 2023Review
- Glucagon-Like Peptide-1 (GLP-1) during Ramadan: Narrative Review of the Published Literature.Journal of obesity · 2023Review
- Absolute risk of acute coronary syndrome after severe hypoglycemia: A population-based 2-year cohort study using the National Database in Japan.Journal of diabetes investigation · 2020Article
- Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds.International journal of nanomedicine · 2020Review
- Immense Insulin Intestinal Uptake and Lymphatic Transport Using Bile Acid Conjugated Partially Uncapped Liposome.Molecular pharmaceutics · 2018Article
- Association Between Hypoglycemia and the Burden of Comorbidities in Hospitalized Vulnerable Older Diabetic Patients: A Cross-Sectional, Population-Based Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Article
- Study of adverse drug reactions in patients with diabetes attending a tertiary care hospital in New Delhi, India.The Indian journal of medical research · 2017Article
- Article
- Secular Trends in the Clinical Characteristics of Type 2 Diabetic Patients With Severe Hypoglycemia Between 2008 and 2013.Journal of clinical medicine research · 2016Article
- Resting-state functional MR imaging shed insights into the brain of diabetes.Metabolic brain disease · 2016Review
- Moieties in antidiabetic drugs as a target of insulin receptors in association with common neurological disorders.Biomedical reports · 2016Article
- A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Food & nutrition research · 2016Article
- Severe Hypoglycemia and Cardiovascular Disease in Type 2 Diabetes.Diabetes & metabolism journal · 2015Article
- Lupanine Improves Glucose Homeostasis by Influencing KATP Channels and Insulin Gene Expression.Molecules (Basel, Switzerland) · 2015Article
- Neuregulin 1 Improves Glucose Tolerance in db/db Mice.PloS one · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent clinical trials indicated that the intensive glycemic control do not reduce cardiovascular disease mortality among diabetic patients, challenging a significance of the strict glycemic control in diabetes management. Furthermore, retrospective analysis of the Action to Control Cardiovascular Risk in Diabetes study demonstrated a significant association between hypoglycemia and mortality. Here, we systematically reviewed the drug-induced hypoglycemia, and also the underlying clinical factors for hypoglycemia in patients with diabetes. The sulfonylurea use is significantly associated with severe hypoglycemia in patients with type 2 diabetes. The use of biguanide (approximately 45%-76%) and thiazolidinediones (approximately 15%-34%) are also highly associated with the development of severe hypoglycemia. In patients treated with insulin, the intensified insulin therapy is more frequently associated with severe hypoglycemia than the conventional insulin therapy and continuous subcutaneous insulin infusion. Among the underlying clinical factors for development of severe hypoglycemia, low socioeconomic status, aging, longer duration of diabetes, high HbA1c and low body mass index, comorbidities are precipitating factors for severe hypoglycemia. Poor cognitive and mental functions are also associated with severe hypoglycemia.
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