ArticleInfectious agents and cancer2015
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts.
Article in Infectious agents and cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Risk of prostate cancer in men with HIV/AIDS: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2021Pooled it
- Risk of Colorectal Cancer and Associated Mortality in HIV: A Systematic Review and Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2017Pooled it
- Clinicopathological features and prognostic factors of AIDS-related lymphoma: a retrospective single-center study in China.Annals of hematology · 2025Article
- Article
- Incidence and mortality of non-AIDS-defining cancers among people living with HIV: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- Antiretroviral therapy and Kaposi's sarcoma trends and outcomes among adults with HIV in Latin America.Journal of the International AIDS Society · 2021Observational
- Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study.World journal of gastroenterology · 2018Article
- Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America.Infectious agents and cancer · 2018Article
- Thirty-day Readmission Rates in an HIV-infected Cohort From Rio de Janeiro, Brazil.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- HIV-associated malignancies in sub-Saharan Africa: progress, challenges, and opportunities.Current opinion in HIV and AIDS · 2017Review
- Clinical and laboratory characteristics, staging, and outcomes of individuals with AIDS-associated Kaposi's sarcoma at an university hospital.Anais brasileiros de dermatologiaArticle
- Trends in malignancies among patients having human immunodeficiency virus infection attending a tertiary care hospital in southwest India.Medical journal, Armed Forces IndiaArticle
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWith successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not been well described. It is not known if cancer trends in HIV-infected populations in Brazil are similar to those of other countries where antiretroviral therapy is also widely available.
methodsWe performed a retrospective analysis of clinical cohorts at Instituto Nacional de Infectologia Evandro Chagas (INI) in Rio de Janeiro and Vanderbilt Comprehensive Care Clinic (VCCC) in Nashville from 1998 to 2010. We used Poisson regression and standardized incidence ratios (SIRs) to examine incidence trends. Clinical and demographic predictors of ADCs and NADCs were examined using Cox proportional hazards models.
resultsThis study included 2,925 patients at INI and 3,927 patients at VCCC. There were 57 ADCs at INI (65% Kaposi sarcoma), 47 at VCCC (40% Kaposi sarcoma), 45 NADCs at INI, and 82 at VCCC. From 1998 to 2004, incidence of ADCs remained statistically unchanged at both sites. From 2005 to 2010, ADC incidence decreased in both cohorts (INI incidence rate ratio per year = 0.74, p < 0.01; VCCC = 0.75, p < 0.01). Overall Kaposi sarcoma incidence was greater at INI than VCCC (3.0 vs. 1.2 cases per 1,000 person-years, p < 0.01). Incidence of NADCs remained constant throughout the study period (overall INI incidence 3.6 per 1,000 person-years and VCCC incidence 5.3 per 1,000 person-years). Compared to general populations, overall risk of NADCs was increased at both sites (INI SIR = 1.4 [95% CI 1.1-1.9] and VCCC SIR = 1.3 [1.0-1.7]). After non-melanoma skin cancers, the most frequent NADCs were anal cancer at INI (n = 7) and lung cancer at VCCC (n = 11). In multivariate models, risk of ADC was associated with male sex and immunosuppression. Risk of NADC was associated with increased age.
conclusionsIn both cohorts, ADCs have decreased over time, though incidence of KS was higher at INI than VCCC. Rates of NADCs remained constant over time at both sites.
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