Evidence map›Paper›PMID 25684988›Full record

ArticleCurrent oncology (Toronto, Ont.)2015

Clinical challenges in patients with cancer-associated thrombosis: Canadian expert consensus recommendations.

M Carrier, A Lazo-Langner, S Shivakumar, V Tagalakis, P L Gross, N Blais, C A Butts, M Crowther

Open access · goldAbstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Managing thrombosis in cancer patients.Research and practice in thrombosis and haemostasis · 2018
    Review
  12. Article
  13. Review
  14. Venous thrombosis and cancer: from mouse models to clinical trials.Journal of thrombosis and haemostasis : JTH · 2015
    Review
  15. Clinical analysis of tumor and non-tumor patients complicated with pulmonary embolism.International journal of clinical and experimental medicine · 2015
    Article
  16. Quality Appraisal of Guidelines on Cancer-Associated Thrombosis Using AGREE II Instrument and Analysis of Current Status of New Oral Anticoagulants.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 3 countries.

M CarrierDepartment of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON.
A Lazo-LangnerDepartments of Medicine, Oncology, and Epidemiology and Biostatistics, University of Western Ontario, London, ON.
S ShivakumarDepartment of Medicine, QEII Health Sciences Centre, Dalhousie University, Halifax, NS.
V TagalakisDepartment of Medicine, Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Montreal, QC.
P L GrossThrombosis and Atherosclerosis Research Institute, Department of Medicine, McMaster University, Hamilton, ON.
N BlaisDepartment of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC.
C A ButtsDepartment of Oncology, University of Alberta, Edmonton, AB.
M CrowtherSt. Joseph's Hospital, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON.
Centre Hospitalier de l’Université de Montréal · CADalhousie University · CAInstitute for Medical Research · MYOttawa Hospital · CASt. Joseph Hospital · USThrombosis and Atherosclerosis Research Institute · CAUniversity of Alberta · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venous thromboembolism is a common complication in cancer patients, and thromboembolism is the second most common cause of death after cancer progression. A number of clinical practice guidelines provide recommendations for the management of cancer-associated thrombosis. However, the guidelines lack recommendations covering commonly encountered clinical challenges (for example, thrombocytopenia, recurrent venous thromboembolism, etc.) for which little or no evidence exists. Accordingly, recommendations were developed to provide expert guidance to medical oncologists and other health care professionals caring for patients with cancer-associated thrombosis. The current expert consensus was developed by a team of 21 clinical experts. For each identified clinical challenge, the literature in medline, embase, and Evidence Based Medicine Reviews was systematically reviewed. The quality of the evidence was assessed, summarized, and graded. Consensus statements were generated, and the experts voted anonymously using a modified Delphi process on their level of agreement with the various statements. Statements were progressively revised through separate voting iterations and were then finalized. Clinicians using these recommendations and suggestions should tailor patient management according to the risks and benefits of the treatment options, patient values and preferences, and local cost and resource allocations.

Indexed as

deep-vein thrombosispulmonary embolismrecommendationsVenous thromboembolism

Identifiers

PMID25684988
PMCPMC4324343
OpenAlexW2135462148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.