Evidence map›Paper›PMID 25684780›Full record

ArticleChemical engineering science2015

Smart Nanoparticles for Drug Delivery: Boundaries and Opportunities.

Byung Kook Lee, Yeon Hee Yun, Kinam Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical engineering science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
  2. Applications of Antioxidant Nanoparticles, 2nd Edition.Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Byung Kook LeePurdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47907, U.S.A.
Yeon Hee YunPurdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47907, U.S.A.
Kinam ParkPurdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47907, U.S.A. ; Purdue University, Department of Industrial and Physical Pharmacy, West Lafayette, IN 47907, U.S.A.

Funding

Adaptable Polymer Micelles for Tumor TargetingR01CA129287 · NCI · PURDUE UNIVERSITY · PI PARK, KINAM · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA129287
6 · The paper itself

Abstract

Various pharmaceutical particles have been used in developing different drug delivery systems ranging from traditional tablets to state-of-the-art nanoparticle formulations. Nanoparticle formulations are unique in that the small size with huge surface area sometimes provides unique properties that larger particles and bulk materials do not have. Nanoparticle formulations have been used in improving the bioavailability of various drugs, in particular, poorly soluble drugs. Nanoparticle drug delivery systems have found their unique applications in targeted drug delivery to tumors. While nanoparticle formulations have been successful in small animal xenograft models, their translation to clinical applications has been very rare. Developing nanoparticle systems designed for targeted drug delivery, e.g., treating tumors in humans, requires clear understanding of the uniqueness of nanoparticles, as well as limitations and causes of failures in clinical applications. It also requires designing novel smart nanoparticle delivery systems that can increase the drug bioavailability and at the same time reduce the drug's side effects.

Indexed as

LiposomenanocrystalNanoparticlePolymer micellePoorly soluble drugTargeted drug delivery

Identifiers

PMID25684780
PMCPMC4322781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.