ArticleHuman brain mapping2015
New insights into the neural network mediating reading processes provided by cortico-subcortical electrical mapping.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- Localization patterns of speech and language errors during awake brain surgery: a systematic review.Neurosurgical review · 2023Pooled it
- Evaluating Spelling in Glioma Patients Undergoing Awake Surgery: a Systematic Review.Neuropsychology review · 2018Pooled it
- A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping.Neuroradiology · 2017Pooled it
- A Systematic Review of Native Languages Mapped With Direct Electrical Stimulation During Awake Craniotomy.Cureus · 2026Review
- The Relation of the Home Literacy Environment to White Matter Pathways Associated with Language in Children 5-8 Years Old.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Intraoperative Language mapping in a Japanese-English-French trilingual patient with a left Temporal lobe glioma: a case report.Brain structure & function · 2025Article
- The capability to successfully study and to be graduated in students who underwent awake surgical resection for a low-grade glioma.Journal of neuro-oncology · 2025Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Unique longitudinal contributions of sulcal interruptions to reading acquisition in children.bioRxiv : the preprint server for biology · 2024Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Performance of intraoperative neurocognitive tests during awake surgery for patients with diffuse low-grade glioma.Neurosurgical review · 2024Observational
- Parcellating the vertical associative fiber network of the temporoparietal area: Evidence from focused anatomic fiber dissections.Brain & spine · 2024Article
- White matter microstructural plasticity associated with educational intervention in reading disability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Review
- Task modulates the orthographic and phonological representations in the bilateral ventral Occipitotemporal cortex.Brain imaging and behavior · 2022Article
- Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes.Brain structure & function · 2022Review
- Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study.Neuro-oncology · 2022Article
- Two different subcortical language networks supporting distinct Japanese orthographies: morphograms and phonograms.Brain structure & function · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo ascertain the neural network mediating reading using intraoperative electrostimulation. EXPERIMENTAL
designA cortical and axonal intraoperative electrical mapping of reading processes was achieved in seven patients who underwent awake surgery for a left occipitotemporal glioma. We performed resection cavity overlapping and superimposition with a diffusion tensor imaging-based white matter atlas. We assessed the relationship between the location of resection cavities and the occurrence of reading impairments of regular, irregular, and pseudowords. PRINCIPAL OBSERVATIONS: Intraoperative stimulation of the left posterior inferior temporal cortex (ITCp) elicited reading disturbances. Subcortical stimulation at the anterior portion of the visual word form area (VWFA) induced addressed phonology (irregular words reading) disturbances. Subcortical stimulation of the connection between VWFA and the posterior segment of the arcuate fascicle (AFp) induced both addressed and assembled phonology (irregular and pseudowords reading) disturbances. Postoperative assessment showed that resection of the posterior portion of the inferior longitudinal fascicle (ILFp), connecting the visual cortex to VWFA, induced long-term and global reading impairment. Resection of the terminations of left AFp in the ITCp-induced irregular and pseudowords reading disturbances with no impairment of regular words reading. Resection of the anterior portion of ILF did not induce reading impairment.
conclusionsOur data support an inner posterior-to-anterior hierarchical coding of letter strings in the VWFA and a crucial role of the left ILFp to provide visual inputs to the VWFA. Furthermore, we suggest that the AFp is involved in an interactive feedback system between visual and nonvisual information, recruited when reading irregular and pseudowords.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.