ArticleThe Journal of comparative neurology2015
Internal organization of medial rectus and inferior rectus muscle neurons in the C group of the oculomotor nucleus in monkey.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.Brain : a journal of neurology · 2026Article
- Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025Review
- Is the central mesencephalic reticular formation a purely horizontal gaze center?Brain structure & function · 2022Article
- Extraocular Motoneurons and Neurotrophism.Advances in neurobiology · 2022Article
- MIF versus SIF Motoneurons, What Are Their Respective Contribution in the Oculomotor Medial Rectus Pool?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.Visual neuroscience · 2021Article
- rAAV2-Retro Enables Extensive and High-Efficient Transduction of Lower Motor Neurons following Intramuscular Injection.Molecular therapy. Methods & clinical development · 2020Article
- Functional architecture underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain.BMC biology · 2019Article
- Central mesencephalic reticular formation control of the near response: lens accommodation circuits.Journal of neurophysiology · 2019Article
- Functional diversity of motoneurons in the oculomotor system.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transduction of Craniofacial Motoneurons Following Intramuscular Injections of Canine Adenovirus Type-2 (CAV-2) in Rhesus Macaques.Frontiers in neuroanatomy · 2019Article
- A Subset of Palisade Endings Only in the Medial and Inferior Rectus Muscle in Monkey Contain Calretinin.Investigative ophthalmology & visual science · 2018Article
- A central mesencephalic reticular formation projection to medial rectus motoneurons supplying singly and multiply innervated extraocular muscle fibers.The Journal of comparative neurology · 2017Article
- Examination of feline extraocular motoneuron pools as a function of muscle fiber innervation type and muscle layer.The Journal of comparative neurology · 2017Article
- A central mesencephalic reticular formation projection to the Edinger-Westphal nuclei.Brain structure & function · 2016Article
- Palisade Endings Are a Constant Feature in the Extraocular Muscles of Frontal-Eyed, But Not Lateral-Eyed, Animals.Investigative ophthalmology & visual science · 2016Article
- Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.Frontiers in neuroanatomy · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Mammalian extraocular muscles contain singly innervated twitch muscle fibers (SIF) and multiply innervated nontwitch muscle fibers (MIF). In monkey, MIF motoneurons lie around the periphery of oculomotor nuclei and have premotor inputs different from those of the motoneurons inside the nuclei. The most prominent MIF motoneuron group is the C group, which innervates the medial rectus (MR) and inferior rectus (IR) muscle. To explore the organization of both cell groups within the C group, we performed small injections of choleratoxin subunit B into the myotendinous junction of MR or IR in monkeys. In three animals the IR and MR myotendinous junction of one eye was injected simultaneously with different tracers (choleratoxin subunit B and wheat germ agglutinin). This revealed that both muscles were supplied by two different, nonoverlapping populations in the C group. The IR neurons lie adjacent to the dorsomedial border of the oculomotor nucleus, whereas MR neurons are located farther medially. A striking feature was the differing pattern of dendrite distribution of both cell groups. Whereas the dendrites of IR neurons spread into the supraoculomotor area bilaterally, those of the MR neurons were restricted to the ipsilateral side and sent a focused bundle dorsally to the preganglionic neurons of the Edinger-Westphal nucleus, which are involved in the "near response." In conclusion, MR and IR are innervated by independent neuron populations from the C group. Their dendritic branching pattern within the supraoculomotor area indicates a participation in the near response providing vergence but also reflects their differing functional roles.
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