ArticleAlcoholism, clinical and experimental research2015
Gender effects in alcohol dependence: an fMRI pilot study examining affective processing.
Article in Alcoholism, clinical and experimental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative effects of topiramate and naltrexone on neural activity during anticipatory anxiety in individuals with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.Psychiatry research. Neuroimaging · 2026Article
- The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.Translational psychiatry · 2025Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.Alcohol, clinical & experimental research · 2024Article
- Sex differences in alcohol's effects on fronto-amygdalar functional connectivity during processing of emotional stimuli.Alcohol, clinical & experimental research · 2024Article
- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- A systematic review of sex/gender differences in the multi-dimensional neurobiological mechanisms in addiction and their relevance to impulsivity.Current addiction reports · 2023Article
- Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations.Translational psychiatry · 2022Article
- Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.PloS one · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment.Alcohol research : current reviews · 2020Review
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Article
- Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.Brain connectivity · 2018Article
- Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain.Addiction biology · 2018Article
- Continuous and Intermittent Alcohol Free-Choice from Pre-gestational Time to Lactation: Focus on Drinking Trajectories and Maternal Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlcohol dependence (AD) has global effects on brain structure and function, including frontolimbic regions regulating affective processing. Preliminary evidence suggests alcohol blunts limbic response to negative affective stimuli and increases activation to positive affective stimuli. Subtle gender differences are also evident during affective processing.
methodsFourteen abstinent AD individuals (8 F, 6 M) and 14 healthy controls (9 F, 5 M), ages 23 to 60, were included in this facial affective processing functional magnetic resonance imaging pilot study. Whole-brain linear regression analyses were performed, and follow-up analyses examined whether AD status significantly predicted depressive symptoms and/or coping.
resultsFearful Condition-The AD group demonstrated reduced activation in the right medial frontal gyrus, compared with controls. Gender moderated the effects of AD in bilateral inferior frontal gyri. Happy Condition-AD individuals had increased activation in the right thalamus. Gender moderated the effects of AD in the left caudate, right middle frontal gyrus, left paracentral lobule, and right lingual gyrus. Interactive AD and gender effects for fearful and happy faces were such that AD men activated more than control men, but AD women activated less than control women. Enhanced coping was associated with greater activation in right medial frontal gyrus during fearful condition in AD individuals.
conclusionsAbnormal affective processing in AD may be a marker of alcoholism risk or a consequence of chronic alcoholism. Subtle gender differences were observed, and gender moderated the effects of AD on neural substrates of affective processing. AD individuals with enhanced coping had brain activation patterns more similar to controls. Results help elucidate the effects of alcohol, gender, and their interaction on affective processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.