ArticleJournal of neurology2015
Speech disorders reflect differing pathophysiology in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Tremor in multiple system atrophy: a systematic literature review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- The Cognitive Profile of Atypical Parkinsonism: A Meta-Analysis.Neuropsychology review · 2023Pooled it
- Voice and Speech in Atypical Parkinsonian Disorders.Movement disorders clinical practice · 2026Review
- Speech impairment in a large sample of patients with multiple system atrophy: effect of gender and language.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Analytical validation of digital measure of intelligibility in progressive supranuclear palsy.Frontiers in neuroscience · 2026Article
- Syllable-based speech characteristics as potential biomarker for differential diagnosis of Parkinson's disease, multiple system atrophy, and cerebellar ataxia.Journal of neurology · 2025Article
- Speech Differences between Multiple System Atrophy and Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Tongue strength in progressive supranuclear palsy.Parkinsonism & related disorders · 2025Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Speech profile in different clinical PSP phenotypes: an acoustic-perceptual study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Motor symptoms of Parkinson's disease: critical markers for early AI-assisted diagnosis.Frontiers in aging neuroscience · 2025Review
- Characteristics of dysarthria in patients with spinocerebellar degeneration and multiple system atrophy: a cross-sectional and longitudinal study using the Frenchay Dysarthria Assessment Second Edition (FDA-2).Frontiers in neurology · 2025Article
- Cerebral Amyloid-β Deposition, Axial Features, and Cognitive Alterations in Patients with Parkinson's Disease Treated with Bilateral STN-DBS: A Long-Term Cohort Study.Journal of personalized medicine · 2024Article
- Influences of motor speech impairments on the presentation of dysphagia in progressive supranuclear palsy.International journal of speech-language pathology · 2024Article
- Utilizing speech analysis to differentiate progressive supranuclear palsy from Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson's disease.Scientific reports · 2023Article
- Acquired Stuttering in Parkinson's Disease.Movement disorders clinical practice · 2023Article
- Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Oromotor Nonverbal Performance and Speech Motor Control: Theory and Review of Empirical Evidence.Brain sciences · 2023Review
- Dysarthria in hereditary spastic paraplegia type 4.Clinics (Sao Paulo, Brazil) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although speech disorder is frequently an early and prominent clinical feature of Parkinson's disease (PD) as well as atypical parkinsonian syndromes (APS) such as progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), there is a lack of objective and quantitative evidence to verify whether any specific speech characteristics allow differentiation between PD, PSP and MSA. Speech samples were acquired from 77 subjects including 15 PD, 12 PSP, 13 MSA and 37 healthy controls. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analysis of 16 speech dimensions. Dysarthria was uniformly present in all parkinsonian patients but was more severe in PSP and MSA than in PD. Whilst PD speakers manifested pure hypokinetic dysarthria, ataxic components were more affected in MSA whilst PSP subjects demonstrated severe deficits in hypokinetic and spastic elements of dysarthria. Dysarthria in PSP was dominated by increased dysfluency, decreased slow rate, inappropriate silences, deficits in vowel articulation and harsh voice quality whereas MSA by pitch fluctuations, excess intensity variations, prolonged phonemes, vocal tremor and strained-strangled voice quality. Objective speech measurements were able to discriminate between APS and PD with 95% accuracy and between PSP and MSA with 75% accuracy. Dysarthria severity in APS was related to overall disease severity (r = 0.54, p = 0.006). Dysarthria with various combinations of hypokinetic, spastic and ataxic components reflects differing pathophysiology in PD, PSP and MSA. Thus, motor speech examination may provide useful information in the evaluation of these diseases with similar manifestations.
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