ArticleScientific reports2015
Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
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- Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis.International journal of molecular sciences · 2021Article
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- MicroRNAs Regulate Metabolic Phenotypes During Multicellular Tumor Spheroids Progression.Frontiers in oncology · 2020Article
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- Metabolic and signalling network maps integration: application to cross-talk studies and omics data analysis in cancer.BMC bioinformatics · 2019Article
- L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis.Genome research · 2018Article
- Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant.GigaScience · 2018Article
- Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data.Journal of proteome research · 2018Article
- Association between single nucleotide polymorphisms in the PI3K/AKT/mTOR pathway and bladder cancer risk in a sample of Iranian population.EXCLI journal · 2018Article
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7 authors.
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Abstract
Members of the inositol phosphate metabolism pathway regulate cell proliferation, migration and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and are frequently dysregulated in cancer. Whether germline genetic variants in inositol phosphate metabolism pathway are associated with cancer risk remains to be clarified. We examined the association between inositol phosphate metabolism pathway genes and risk of eight types of cancer using data from genome-wide association studies. Logistic regression models were applied to evaluate SNP-level associations. Gene- and pathway-based associations were tested using the permutation-based adaptive rank-truncated product method. The overall inositol phosphate metabolism pathway was significantly associated with risk of lung cancer (P = 2.00 × 10(-4)), esophageal squamous cell carcinoma (P = 5.70 × 10(-3)), gastric cancer (P = 3.03 × 10(-2)) and renal cell carcinoma (P = 1.26 × 10(-2)), but not with pancreatic cancer (P = 1.40 × 10(-1)), breast cancer (P = 3.03 × 10(-1)), prostate cancer (P = 4.51 × 10(-1)), and bladder cancer (P = 6.30 × 10(-1)). Our results provide a link between inherited variation in the overall inositol phosphate metabolism pathway and several individual genes and cancer. Further studies will be needed to validate these positive findings, and to explore its mechanisms.
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