Evidence map›Paper›PMID 25683669›Full record

ArticleJournal of medical primatology2015

Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): high frequency of small size apolipoprotein(a) isoforms.

Byambaa Enkhmaa, Adnan Abbuthalha, Erdembileg Anuurad, Wei Zhang, Alice F Tarantal, Lars Berglund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Byambaa EnkhmaaDepartment of Internal Medicine, University of California, Davis, CA, USA.
Adnan AbbuthalhaDepartment of Internal Medicine, University of California, Davis, CA, USA.
Erdembileg AnuuradDepartment of Internal Medicine, University of California, Davis, CA, USA.
Wei ZhangDepartment of Internal Medicine, University of California, Davis, CA, USA.
Alice F TarantalDepartment of Pediatrics, University of California, Davis, CA, USA.
Lars BerglundDepartment of Internal Medicine, University of California, Davis, CA, USA.
University of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood DiseasesR24HL085794 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2006 to 2016
$9.7M
Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
Regulation of Lipoprotein(a) Metabolism in Humans with Reference to EthnicityR01HL062705 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI BERGLUND, LARS F · 2000 to 2011
$2.9M
NCATS NIH HHS TR000002NCATS NIH HHS UL1 TR000002NCRR NIH HHS RR024146NCRR NIH HHS UL1 RR024146NHLBI NIH HHS HL062705NHLBI NIH HHS HL085794NHLBI NIH HHS R01 HL062705NHLBI NIH HHS R24 HL085794NICHD NIH HHS 2K12HD051958NICHD NIH HHS K12 HD051958NIH HHS P51 OD011107
6 · The paper itself

Abstract

backgroundLevels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk.

methodsWe determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95).

resultsLp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43%.

conclusionsDistribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

Indexed as

AllelesAnimalsApolipoprotein A-IGenetic VariationHumansLipoprotein(a)Macaca mulattaProtein IsoformsSpecies SpecificityApolipoprotein A-ILipoprotein(a)Protein Isoformsapo(a) phenotypeK4 repeatnon-human primateOld World monkey

Identifiers

PMID25683669
PMCPMC4430394
OpenAlexW2092154063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.