Evidence map›Paper›PMID 25683179›Full record

ReviewAutoimmunity2015

Vaccination to modulate atherosclerosis.

Takayuki Kimura, Kevin Tse, Alessandro Sette, Klaus Ley

Abstract readReview
In one paragraph

Review in Autoimmunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. A bibliometric analysis of vaccination against atherosclerosis.Human vaccines & immunotherapeutics · 2024
    Article
  4. Atheroprotective Aspects of Heat Shock Proteins.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. CD8Cells · 2020
    Review
  13. Article
  14. Article
  15. Macrophages in Atherosclerosis Regression.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Takayuki KimuraDivision of Inflammation Biology and.
Kevin Tse
Alessandro Sette
Klaus Ley
La Jolla Institute for Immunology · US

Funding

ROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MILLER, YURY · 1995 to 2016
$28.4M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
Vaccination with MHC-II restricted ApoB100 peptides to prevent atherosclerosisR01HL121697 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2015 to 2018
$1.8M
NHLBI NIH HHS P01 HL055798NHLBI NIH HHS R01 HL115232NHLBI NIH HHS R01 HL121697
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease of the artery wall. Adaptive immunity plays a key role in the pathogenesis of atherosclerosis. Recently, modulation of the immune response against atherosclerotic plaque antigen(s) has attracted attention as a potentially preventive and therapeutic approach. Here, we review a series of studies on immunization with various antigens targeting treatment and prevention of atherosclerosis. Atherosclerosis-related antigens include oxidized low-density lipoprotein (LDL), apolipoprotein B-100 (ApoB-100) and heat shock protein (HSP) 60/65. Accumulating evidence supports the idea that immunization with these antigenic proteins or peptides may reduce atherosclerosis. In this review, we discuss the current status of immunization studies and possible associated mechanisms of atheroprotection.

Indexed as

VaccinationAdaptive ImmunityAnimalsAntibodiesApolipoprotein B-100ArteriesAtherosclerosisAutoantigensChaperonin 60Gene ExpressionHeat-Shock ProteinsHumansImmunity, HumoralLipoproteins, LDLMiceMitochondrial ProteinsAntibodiesApolipoprotein B-100AutoantigensChaperonin 60Heat-Shock ProteinsHSPD1 protein, humanLipoproteins, LDLMitochondrial Proteinsoxidized low density lipoproteinPeptidesVaccinesApolipoprotein B-100atherosclerosisheat shock protein 65immunizationlow-density lipoprotein

Identifiers

PMID25683179
PMCPMC4429861
OpenAlexW2024086036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.