Evidence map›Paper›PMID 25682798›Full record

Trial reportMaternal & child nutrition2015

Adding multiple micronutrient powders to a homestead food production programme yields marginally significant benefit on anaemia reduction among young children in Nepal.

Akoto K Osei, Pooja Pandey, David Spiro, Debendra Adhikari, Nancy Haselow, Caroline De Morais, Dale Davis

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal & child nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03313089 (Nutritional Impact of a Project on Food Security and Nutrition in Children of 6 Months to 5 Years of Age Receiving Home Fortification With Micronutrient Powders in Nariño, Colombia), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03313089 completednot on this mapstarted 2017, after this paper: background citation

Nutritional Impact of a Project on Food Security and Nutrition in Children of 6 Months to 5 Years of Age Receiving Home Fortification With Micronutrient Powders in Nariño, Colombia

TypeobservationalSponsorUniversidad Nacional de ColombiaRan2017 to 2017Enrolled112ConditionsHemoglobin, AnemiaArms"Papas más nutritivas" (PSAN)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Akoto K OseiAsia Pacific Regional Office, Helen Keller International, Phnom Penh, Cambodia.
Pooja PandeyHelen Keller International, Kathmandu, Nepal.
David SpiroRTI International, Jakarta, Indonesia.
Debendra AdhikariHelen Keller International, Kathmandu, Nepal.
Nancy HaselowAsia Pacific Regional Office, Helen Keller International, Phnom Penh, Cambodia.
Caroline De MoraisHelen Keller International, Kathmandu, Nepal.
Dale DavisHelen Keller International, Kathmandu, Nepal.
Helen Keller International Nepal · NPPhnom Penh International University · KHIndonesia International Institute for Life Sciences · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaemia affects 46% of preschool-aged children in Nepal. A cluster-randomised study was conducted in rural Nepal to test whether providing micronutrient powders (MNP) in addition to enhanced homestead food production (EHFP) programme, consisting of home gardens, poultry and nutrition education, could lead to a higher reduction in anaemia compared with providing only EHFP. This sub-study enrolled 335 children aged 6-9 months into one of three groups: (1) EHFP + MNP; (2) EHFP; or (3) control. The EHFP + MNP group received 60 sachets of MNP for flexible consumption at the start and 6 months later for a total supplementation period of 11 months. The MNP contained 15 micronutrients including iron (10 mg encapsulated ferrous fumarate). Haemoglobin and anthropometry were measured at baseline and post-MNP supplementation. Mean ± SE haemoglobin concentration increased significantly in all groups, with a slightly higher but non-significant increase in the EHFP + MNP and EHFP compared with control (difference-in-differences: 4.1 g L(-1) for EHFP + MNP vs. control; 3.6 g L(-1) for EHFP vs. control; 0.5 g L(-1) for EHFP + MNP vs. EHFP). Anaemia decreased at a slightly higher magnitude in the EHFP + MNP [51.5 percentage points (PP)] than the EHFP (48.6 PP) and control (39.6 PP), with adjusted odds ratios (95% CI) at post-supplementation of 0.52 (0.25-1.12) for EHFP + MNP and 0.69 (0.35-1.36) for EHFP, compared with control. There was no impact on child growth. Combining EHFP and MNP programmes yielded a marginally significant reduction in anaemia among children.

Indexed as

Dietary SupplementsAnemia, Iron-DeficiencyCluster AnalysisDose-Response Relationship, DrugFemaleHemoglobinsHumansInfantIron, DietaryLogistic ModelsLongitudinal StudiesMaleMicronutrientsNepalPowdersPrevalenceHemoglobinsIron, DietaryMicronutrientsPowderschildrenhome fortificationhomestead food productionmicronutrient powdersMNPNepal

Identifiers

PMID25682798
PMCPMC6860240
OpenAlexW1923175740

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.