ArticleJournal of experimental botany2015
Multiple steps control immunity during the intracellular accommodation of rhizobia.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago - Sinorhizobium symbiosis.The New phytologist · 2026Article
- Rhizobial Nod factors modulate reactive oxygen species, jasmonates, and pattern-recognizing receptors to suppress immune response.Plant molecular biology · 2026Article
- Symbiotic compatibility between Rhizobium laguerreae and its host.Archives of microbiology · 2026Article
- Article
- Defense and senescence interplay in legume nodules.Plant communications · 2024Review
- Autophagy and Symbiosis: Membranes, ER, and Speculations.International journal of molecular sciences · 2024Review
- Article
- Competitiveness and Phylogenetic Relationship of Rhizobial Strains with Different Symbiotic Efficiency inBiology · 2023Article
- Exogenously Applied Cytokinin Altered the Bacterial Release and Subsequent Stages of Nodule Development in PeaPlants (Basel, Switzerland) · 2023Article
- Legumes Regulate Symbiosis with Rhizobia via Their Innate Immune System.International journal of molecular sciences · 2023Review
- Insight into the control of nodule immunity and senescence during Medicago truncatula symbiosis.Plant physiology · 2023Article
- The role of microbial interactions on rhizobial fitness.Frontiers in plant science · 2023Review
- MtEFD and MtEFD2: Two transcription factors with distinct neofunctionalization in symbiotic nodule development.Plant physiology · 2022Article
- Review
- The chromosome-level genome assembly ofPlant communications · 2022Article
- A novel function of the key nitrogen-fixation activator NifA in beta-rhizobia: Repression of bacterial auxin synthesis during symbiosis.Frontiers in plant science · 2022Article
- Argonaute5 and its associated small RNAs modulate the transcriptional response during the rhizobia-Frontiers in plant science · 2022Article
- Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in PeaPlants (Basel, Switzerland) · 2021Article
- How Rhizobia Adapt to the Nodule Environment.Journal of bacteriology · 2021Article
- Conditional sanctioning in a legume-Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medicago truncatula belongs to the legume family and forms symbiotic associations with nitrogen fixing bacteria, the rhizobia. During these interactions, the plants develop root nodules in which bacteria invade the plant cells and fix nitrogen for the benefit of the plant. Despite massive infection, legume nodules do not develop visible defence reactions, suggesting a special immune status of these organs. Some factors influencing rhizobium maintenance within the plant cells have been previously identified, such as the M. truncatula NCR peptides whose toxic effects are reduced by the bacterial protein BacA. In addition, DNF2, SymCRK, and RSD are M. truncatula genes required to avoid rhizobial death within the symbiotic cells. DNF2 and SymCRK are essential to prevent defence-like reactions in nodules after bacteria internalization into the symbiotic cells. Herein, we used a combination of genetics, histology and molecular biology approaches to investigate the relationship between the factors preventing bacterial death in the nodule cells. We show that the RSD gene is also required to repress plant defences in nodules. Upon inoculation with the bacA mutant, defence responses are observed only in the dnf2 mutant and not in the symCRK and rsd mutants. In addition, our data suggest that lack of nitrogen fixation by the bacterial partner triggers bacterial death in nodule cells after bacteroid differentiation. Together our data indicate that, after internalization, at least four independent mechanisms prevent bacterial death in the plant cell. These mechanisms involve successively: DNF2, BacA, SymCRK/RSD and bacterial ability to fix nitrogen.
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