Evidence map›Paper›PMID 25682603›Full record

ArticleHaematologica2015

Markedly perturbed hematopoiesis in acid ceramidase deficient mice.

Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua M Moreau, Makoto Yoshimitsu, Jessa Trentadue, Bryan C Y Au, Christopher J Paige, Jeffrey A Medin

Abstract readLetter
In one paragraph

Article in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.International journal of molecular sciences · 2019
    Article
  8. Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.Laboratory investigation; a journal of technical methods and pathology · 2019
    Article
  9. Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Article
  11. Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaalee DworskiInstitute of Medical Science, University of Toronto, Canada.
Alexandra BergerUniversity Health Network, Toronto, Canada.
Caren FurlongerUniversity Health Network, Toronto, Canada.
Joshua M MoreauDepartment of Immunology, University of Toronto, Canada.
Makoto YoshimitsuDivision of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Jessa TrentadueUniversity Health Network, Toronto, Canada.
Bryan C Y AuUniversity Health Network, Toronto, Canada.
Christopher J PaigeUniversity Health Network, Toronto, Canada Department of Immunology, University of Toronto, Canada Department of Medical Biophysics, University of Toronto, Canada.
Jeffrey A MedinInstitute of Medical Science, University of Toronto, Canada University Health Network, Toronto, Canada Department of Medical Biophysics, University of Toronto, Canada jmedin@uhnres.utoronto.ca.

Funding

Genetic Correction of a Novel "Knock-in" Mouse Model for Farber DiseaseR21NS078191 · NINDS · UNIVERSITY HEALTH NETWORK · PI MEDIN, JEFFREY A · 2013 to 2014
$294k
Canadian Institutes of Health ResearchNINDS NIH HHS NIH1R21NS078191- 01A1 (NINDS NIH HHS R21 NS078191
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acid CeramidaseAnimalsBone MarrowFoam CellsGenetic Association StudiesHematopoiesisMiceMice, KnockoutOrgan SizePhenotypeSpleenThymus GlandAcid CeramidaseAsah1 protein, mouseacid ceramidase deficient miceFarber diseasehematopoiesishistiocytosisorgan architecture

Identifiers

PMID25682603
PMCPMC4420221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.